肠道非免疫细胞及其在炎症性肠病中的作用研究进展  

Progress in study of gut non-immune cells and their role in development of inflammatory bowel disease

作　　者：王泽瑞 焦艳梅 令狐恩强[1] Wang Ze-Rui;Jiao Yan-Mei;Linghu En-Qiang(Senior Department of Gastroenterology,the First Medical Center of Chinese PLA General Hospital,Beijing 100853,China;Senior Department of Infectious Diseases,the Fifth Medical Center of Chinese PLA General Hospital,Beijing 100039,China)

机构地区：[1]解放军总医院第一医学中心消化内科医学部,北京100853 [2]解放军总医院第五医学中心感染病医学部,北京100039

出　　处：《解放军医学杂志》2024年第5期594-601,共8页Medical Journal of Chinese People's Liberation Army

摘　　要：炎症性肠病(IBD)是免疫性疾病,虽然免疫细胞及相关的免疫学反应在IBD的发病过程中起主导作用,但是非免疫细胞,如肠道上皮细胞、间质细胞、内皮细胞等也参与了这一过程。近年来研究表明,肠道非免疫细胞在维持肠道上皮稳态、基质重塑、免疫反应及炎症过程中发挥着重要作用。有关肠道非免疫细胞的构成、基因表达特点及细胞功能,以及它们在IBD发生发展过程中的作用成为研究热点,尤其单细胞RNA测序(scRNA-seq)技术初步阐明了肠道细胞不同亚群的基因表达特征及细胞功能,以及这些变化与IBD发生发展的关系。本文针对肠道非免疫细胞在IBD中作用的相关进展进行综述。Inflammatory bowel disease(IBD)is a kind of immune disease.Although immune cells and related immunological reactions play a crucial role in the pathogenesis,non-immune cells of IBD,including intestinal epithelial cells,stromal cells,and endothelial cells are also involved in this process.Recent studies have shown that gut non-immune cells play an important role in the maintenance of intestinal epithelial homeostasis,matrix remodeling,immune response and inflammation.The composition,gene expression characteristics and cell functions of gut non-immune cells,as well as their role in the occurrence and progression of IBD,have been paid much attention in the field of gut research.In particular,recently,single-cell RNA sequencing(scRNA-seq)technology has initially clarified the gene expression characteristics and cell functions of different subgroups of intestinal cells,and the correlation between these changes and the occurrence and progression of IBD.Therefore,this review summarizes the progress of intestinal non-immune cells in IBD.

关 键 词：炎症性肠病 溃疡性结肠炎 克罗恩病 单细胞RNA测序 上皮细胞 间充质细胞 

分 类 号：R574[医药卫生—消化系统]