食欲素系统在睡眠剥夺损伤学习记忆功能中的研究进展  

Research progress on orexin system in learning and memory function impaired by sleep deprivation

作　　者：刘欢[1] 王海云[1] Liu Huan;Wang Haiyun(The Third Central Clinical College of Tianjin Medical University,Nankai University Affinity the Third Central Hospital,Tianjin Key Lab-oratory of Extracorporeal Life Support for Critical Diseases,Artificial Cell Engineering Technology Research Center,Tianjin Institute of Hepatobiliary Disease,Tianjin 300170,China)

机构地区：[1]天津医科大学三中心临床学院,南开大学附属第三中心医院,天津市重症疾病体外生命支持重点实验室,天津市人工细胞工程技术研究中心,天津市肝胆疾病研究所,天津300170

出　　处：《国际麻醉学与复苏杂志》2024年第4期439-443,共5页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金面上项目(82371205,82071220);天津市自然科学基金面上项目(20JCYBJC01290);天津市卫生健康科研项目(TJWJ2023XK019);天津市卫生健康委员会科技基金面上项目(MS20013);天津市医学重点学科(专科)建设项目(TJYXZDXK‑072C);天津市应用基础研究多元投入基金项目(21JCQNJC01020)。

摘　　要：睡眠剥夺(SD)是指由外界或自身原因导致的睡眠缺乏状态。SD对人的身心健康产生深远的影响,人们也越发关注其对认知功能的影响,但其相关机制尚不明确,且缺乏安全、有效的治疗手段。食欲素(orexin)是由下丘脑产生的主要在中枢系统起作用的神经肽,近年来已发现其对调节摄食、睡眠周期、认知等多方面有广泛作用,文章对orexin在睡眠与学习记忆中的可能机制进行综述,为SD相关认知功能障碍的机制探索和临床治疗提供新的角度。Sleep deprivation(SD)refers to the sleep deprivation caused by the outside world or its own reasons.SD has profound impacts on both physical and mental health.There is a growing concern about its impact on cognitive function,but its related mechanisms are still unclear and there is a lack of safe and effective treatment methods.Orexin is a neuropeptide produced by the hypothalamus and mainly plays a role in the central system.In recent years,it has been found to exert a wide range of effects on the regulation of food intake,sleep cycles,and cognition.This review explores the possible mechanisms of orexin in sleep and learning memory,providing a new perspective for the mechanism exploration and clinical treatment of SD-related cognitive dysfunction.

关 键 词：睡眠剥夺 食欲素 睡眠-觉醒周期 

分 类 号：G63[文化科学—教育学]