Effects of NLRP3 Inflammasome Mediated Pyroptosis on Cardiovascular Diseases and Intervention Mechanism of Chinese Medicine  

作　　者：ZHONG Yi LI Xin-yue LIANG Tian-jun DING Bao-zhu MA Ke-xin REN Wen-xuan LIANG Wen-jie 

机构地区：[1]College of Integrated Traditional Chinese and Western Medicine,Hebei University of Chinese Medicine,Hebei Key Laboratory of Integrated Traditional Chinese and Western Medicine in Liver and Kidney Diseases,Institute of Integrated Traditional Chinese and Western Medicine,Shijiazhuang 050200,China [2]Department of Cardiovascular Internal Medicine,the Second Affiliated Hospital of Jiujiang University,Jiujiang,Jiangxi Province 332000,China [3]Graduate School,Hebei Medical University,Shijiazhuang 050017,China [4]Rural Physician College,Hebei Medical University,Shijazhuang 050017,China [5]Medical Department,the First Hospital of Hebei Medical University,Shijiazhuang 050030,China

出　　处：《Chinese Journal of Integrative Medicine》2024年第5期468-479,共12页中国结合医学杂志（英文版）

基　　金：Supported by the Scientific Research Project of Hebei Provincial Administration of Traditional Chinese Medicine (No.2020149)。

摘　　要：Activation of the NOD-like receptor protein 3(NLRP3)inflammasome signaling pathway is an important mechanism underlying myocardial pyroptosis and plays an important role in inflammatory damage to myocardial tissue in patients with cardiovascular diseases(CVDs),such as diabetic cardiomyopathy,ischemia/reperfusion injury,myocardial infarction,heart failure and hypertension.Noncoding RNAs(nc RNAs)are important regulatory factors.Many Chinese medicine(CM)compounds,including their effective components,can regulate pyroptosis and exert myocardium-protecting effects.The mechanisms underlying this protection include inhibition of inflammasome protein expression,Toll-like receptor 4–NF-κB signal pathway activation,oxidative stress,endoplasmic reticulum stress(ERS),and mixed lineage kinase 3 expression and the regulation of silent information regulator 1.The NLRP3 protein is an important regulatory target for CVD prevention and treatment with CM.Exploring the effects of the interventions mediated by CM and the related mechanisms provides new ideas and perspectives for CVD prevention and treatment.

关 键 词：PYROPTOSIS cardiovascular diseases Chinese medicine NOD-like receptor protein 3 mechanisms 

分 类 号：R54[医药卫生—心血管疾病]