Microbiota in colorectal cancer related to liver metastasis  

作　　者：Peijun Wei Weiming Han Zitong Zhang Xue Tian Chen Yang Qiaoxuan Wang Weihao Xie Ying Liu Yuanhong Gao Hui Chang 

机构地区：[1]Department of Radiation Oncology,State Key Laboratory of Oncology in South China,Guangzhou 510060,China [2]Guangdong Provincial Clinical Research Center for Cancer,Guangzhou 510060,China [3]Sun Yat-sen University Cancer Center,Guangzhou 510060,China [4]Department of Pediatric Oncology,State Key Laboratory of Oncology in South China,Guangzhou 510060,China

出　　处：《Chinese Journal of Cancer Research》2024年第1期17-24,共8页中国癌症研究（英文版）

摘　　要：The prevalence of colorectal cancer(CRC) is increasing annually and metastasis is the principal cause of death in patients with CRC, with the liver being the most frequently affected site. Many studies have shown a strong interplay between the gut flora, particularly Fusobacterium nucleatum(F. nucleatum), Escherichia coli, and Bacteroides fragilis, and the development of gut tumors. Some strains can induce gut inflammation and produce toxins that directly harm gut epithelial cells, ultimately accelerating the onset and progression of CRC. However,little clinical evidence exists on the specific interplay between the gut microflora and colorectal cancer liver metastasis(CRLM). Some research showed the existence of viable F. nucleatum in distant metastasis of CRC.Subsequently, gut microbiota products, such as lipopolysaccharides, sodium butyrate, and protein cathepsin K, were also found to affect the development of CRC. This article summarizes the mechanism and research status of the interplay between gut microflora and CRLM, discusses the importance of gut microflora in the treatment of CRLM, and proposes a new approach to understanding the mechanism of CRLM and potential treatments for the microbiome. It is anticipated that the gut microbiota will be a formidable therapeutic and prophylactic tool for treating and preventing CRLM.

关 键 词：Gut microbiota liver metastasis colorectal cancer 

分 类 号：R735.34[医药卫生—肿瘤]