缺氧诱导因子-1α在炎症性肠病中的作用机制研究进展  

Research progress on the mechanism of hypoxia-inducible factor-1α in inflammatory bowel disease

作　　者：陈蕾蕾 景德怀[2] 张曜文 王岩[2] 于伟 胡宗晶 朱凤琴 周广玺 Chen Leilei;Jing Dehuai;Zhang Yaowen;Wang Yan;Yu Wei;Hu Zongjing;Zhu Fengqin;Zhou Guangxi(Cheeloo College of Medicine,Shandong University,Jinan 250012,China;Department of Gastroenterology,Affiliated Hospital of Jining Medical University,Jining 272029,China)

机构地区：[1]山东大学齐鲁医学院,济南250012 [2]济宁医学院附属医院消化内科,济宁272029

出　　处：《中华炎性肠病杂志（中英文）》2024年第2期174-180,共7页Chinese Journal of Inflammatory Bowel Diseases

基　　金：国家自然科学基金(82270562、82200591);山东省泰山青年学者基金(tsqn202103190)。

摘　　要：炎症性肠病(IBD)的发生与遗传、环境、免疫异常、肠道菌群等因素有关, 包括溃疡性结肠炎(UC)和克罗恩病(CD)。缺氧诱导因子-1α(HIF-1α)是一种能够促进多种基因表达以应答低氧环境的转录因子, 其在调节肠道屏障功能、肠道代谢以及炎症和免疫反应中的作用是目前研究的热点。本文分析HIF-1α与肠上皮屏障、肠道炎症反应的关系, 综述HIF-1α在IBD中发挥的作用, 从而为IBD的临床治疗提供新思路。The development of inflammatory bowel diseases(IBD)is associated with genetics,environment,immune abnormalities,and intestinal flora,including ulcerative colitis(UC)and Crohn′s disease(CD).Hypoxia-inducible factor-1α(HIF-1α)is a transcription factor that promotes the expression of multiple genes in response to the hypoxic environment,and its roles in regulating intestinal barrier function,intestinal metabolism,and inflammatory and immune responses are research hotspots.This article reviews the role of HIF-1αin IBD by analyzing the relationships between HIF-1αand intestinal epithelial barrier and inflammatory response to provide new ideas for the clinical treatment of IBD.

关 键 词：炎症性肠病 缺氧诱导因子-1Α 肠上皮屏障 炎症反应 

分 类 号：R574[医药卫生—消化系统]