Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma:a multi-center integrated analysis of microbiome,metabolome,and transcriptome data  

作　　者：Wenjin Chen Xiuwu Pan Wang Zhou Da Xu Jiaxin Chen Keqin Dong Weijie Chen Brian Rini Xingang Cui 

机构地区：[1]Department of Urology,Xinhua Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,200092,China [2]Department of Urology,Third Affiliated Hospital of the Second Military Medical University,Shanghai,201805,China [3]Division of Hematology Oncology,Vanderbilt University Medical Center,Nashville,TN,37232,USA

出　　处：《Frontiers of Medicine》2024年第2期399-402,共4页医学前沿（英文版）

基　　金：sponsored by the National Natural Science Foundation of China(Nos.81974391,82072806,and 82173265);the National Natural Science Foundation of China for Youths(No.8200100057);Program of Shanghai Academic/Technology Research Leader(No.19XD1405100);Clinical Research Plan of SHDC(No.SHDC2020CR4025);Shanghai“Rising Stars of Medical Talent”Youth Development Program:Youth Medical Talents-Specialist Program(Xiuwu Pan);Shanghai Municipal Commission of Health and Family Planning(No.20204Y0042);Technology Project of Jiading District Health System(No.2019-QN-03);Natural Science Foundation of Shanghai(No.20ZR1470500);Hospital Funded Clinical Research,Xinhua Hospital,Shanghai Jiao Tong University School of Medicine(No.21XHDB06).

摘　　要：Dear editor,Patients with clear-cell renal cell carcinoma(ccRCC)potentially have a high recurrence rate of more than 40%[1].Patients receive radical or partial nephrectomy,sometimes assisted by targeted therapies or/and immune checkpoint inhibitors(ICIs),to improve overall survival(OS)[2].Large-cohort studies and large-scale human tissue sequencing have provided a series of molecular subtyping methods for precision medicine-based ccRCC risk stratification and therapeutic regimens,such as ClearCode34,the prognostic risk predictor[3],and seven subsets for ICI and angiogenesis blockade outcomes[4].However,these subtyping results are all based on human genomes without including the host microbiota,which may be non-negligible genome components.

关 键 词：editor negligible characteristics 

分 类 号：R737.11[医药卫生—肿瘤]