非酒精性脂肪性肝病患者血清FT3水平及FT3/FT4值与2型糖尿病的相关性  

Correlation of serum levels of FT3 and FT3/FT4 with type 2 diabetes mellitus in patients with nonalcoholic fatty liver disease

作　　者：简雪峰[1] 梁硕 李娜娜[1] Jian Xuefeng;Liang Shuo;Li Nana(Department of Nuclear Medicine,School of Clinical Medicine of Henan University of Science and Technology,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003,China)

机构地区：[1]河南科技大学临床医学院河南科技大学第一附属医院核医学科,洛阳471003

出　　处：《中国实用医刊》2024年第4期30-33,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨非酒精性脂肪性肝病(NAFLD)患者血清游离三碘甲状腺原氨酸(FT3)水平、FT3/游离甲状腺素(FT4)值与2型糖尿病(T2DM)的相关性。方法病例对照研究。抽取2021年3月至2023年3月河南科技大学第一附属医院收治的98例NAFLD患者作为研究对象,根据患者是否发生T2DM将其分为非T2DM组(53例)及合并T2DM组(45例)。收集所有纳入患者的一般资料及生化指标,检测并比较两组血清FT3、FT3/FT4及生化指标;采用受试者工作特征曲线评估血清FT3、FT3/FT4对NAFLD患者发生T2DM的诊断价值。结果合并T2DM组患者血清FT3、FT3/FT4水平均低于非T2DM组(P均<0.05)。受试者工作特征曲线分析结果显示,血清FT3诊断NAFLD患者发生T2DM的曲线下面积(AUC)为0.864,95%CI为0.834~0.894;血清FT3/FT4诊断NAFLD患者发生T2DM的AUC为0.905,95%CI为0.855~0.955。结论NAFLD患者血清FT3水平、FT3/FT4值降低与T2DM发生密切相关,有望作为诊断NAFLD患者发生T2DM的有效指标。Objective To investigate the correlation of serum levels of free triiodothyronine(FT3)and FT3/free thyroxine(FT4)with type 2 diabetes mellitus(T2DM)in patients with non-alcoholic fatty liver disease(NAFLD).Methods Ninety-eight patients with NAFLD admitted to the First Affiliated Hospital of Henan University of Science and Technology from March 2021 to March 2023 were selected as the study objects of the case-control study.And they were divided into the non-T2DM group(53 cases)and the T2DM combined group(45 cases)according to development of T2DM.General data and biochemical indexes of all patients were collected.The serum levels of FT3 and FT3/FT4,and biochemical indexes of the two groups were detected,and they were compared between the two groups.Receiver operating characteristic curve was used to evaluate the value of serum FT3 and FT3/FT4 in diagnosing development of T2DM in patients with NAFLD.Results The serum levels of FT3 and FT3/FT4 in the T2DM combined group were lower than those in the non-T2DM group(all P<0.05).Results of receiver operating characteristic curve analysis showed that the area under the curve(AUC)of serum FT3 in diagnosing T2DM in patients with NAFLD was 0.864,95%CI of 0.834-0.894,and the AUC of serum FT3/FT4 in diagnosing T2DM in patients with NAFLD was 0.905,95%CI of 0.855-0.955.Conclusions The decrease of levels of serum FT3 and FT3/FT4 in patients with NAFLD are closely related to the occurrence of T2DM,which are expected to be effective indicators for the diagnosis of T2DM in patients with NAFLD.

关 键 词：2型糖尿病 非酒精性脂肪性肝病 游离三碘甲状腺原氨酸 游离甲状腺素 

分 类 号：R575.5[医药卫生—消化系统] R587.1[医药卫生—内科学]