肝星状细胞来源外泌体对肝纤维化形成的作用  

Roles of hepatic stellate cell-derived exosome in development of liver fibrosis

作　　者：李朋举 黄焕荣 罗晓英 张炳勇 Li Pengju;Huang Huanrong;Luo Xiaoying;Zhang Bingyong(People’s Hospital of Zhengzhou University,Henan Provincial People’s Hospital,Zhengzhou 450003,China)

机构地区：[1]郑州大学人民医院河南省人民医院,郑州450003

出　　处：《中国实用医刊》2024年第4期120-122,F0003,共4页Chinese Journal of Practical Medicine

基　　金：国家自然科学基金(82170637);河南省中青年卫生健康科技创新人才培养(YXKC2022021);河南省自然科学基金(232300421052)。

摘　　要：肝纤维化是肝炎进展为肝硬化的核心过程。近年来研究发现,肝星状细胞产生的外泌体对肝纤维化的形成有双重作用,并与肝纤维化的诊断和治疗密切相关,对其深入研究具有重要意义。本文针对此相关进展做一综述,为肝星状细胞来源外泌体的进一步研究提供指导。Liver fibrosis is the core process of hepatitis progressing to cirrhosis.In recent years,studies have found that exosomes produced by hepatic stellate cells have dual effects on the development of liver fibrosis,and the exosomes are closely related to the diagnosis and treatment of liver fibrosis.Therefore,it is of great significance to make further research.This essay reviews the related progress to provide guidance for further research on exosomes derived from hepatic stellate cells.

关 键 词：外泌体 肝纤维化 肝星状细胞 纤维化微环境 

分 类 号：R575.2[医药卫生—消化系统]