脑卒中抑郁患者经颅超声影像学特征与抑郁程度的相关性  

Correlation between characteristics of transcranial ultrasound imaging in patients with depression after stroke and the degree of depression

作　　者：肖露 王华[1] 王会林[1] 姬亚杰 Xiao Lu;Wang Hua;Wang Huilin;Ji Yajie(Department of Ultrasound,Luoyang Central Hospital,Luoyang 471000,China)

机构地区：[1]洛阳市中心医院超声科,洛阳471000

出　　处：《中国实用医刊》2024年第5期68-71,共4页Chinese Journal of Practical Medicine

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20210869);洛阳市2023年度医疗卫生指导性科技计划项目(2302042Y)。

摘　　要：目的探讨脑卒中抑郁患者经颅超声影像学特征与抑郁程度的相关性。方法队列对照研究。抽取洛阳市中心医院神经内科2023年1月至2023年8月诊治的脑卒中患者240例,依据汉密尔顿抑郁量表评分分为卒中后抑郁组(PSD组,76例)及无抑郁组(NPSD组,130例),并将PSD组分为轻度、中度、重度3个亚组进行经颅超声(TCS)检查,比较各组影像学特征。结果PSD组与NPSD组中缝核(BR)阳性率比较差异有统计学意义(P<0.05),两组黑质(SN)阳性率与第三脑室(V3)增宽率比较差异未见统计学意义(P>0.05)。三亚组间BR阳性比例、SN阳性比例与V3增宽比例比较差异未见统计学意义(P>0.05)。BR阳性对诊断PSD的敏感性、特异性、准确性、阳性预测值和阴性预测值分别为69.7%(53/76)、76.9%(100/130)、74.3%(153/206)、63.9%(53/83)、81.3%(100/123)。Spearman相关性分析结果显示,BR阳性与抑郁程度无相关性(r=0.11,P=0.198)。结论BR阳性对PSD具有一定的诊断效能,与抑郁程度无相关性。Objective To investigate correlation between the characteristics of transcranial ultrasound imaging and the degree of depression in patients with depression after stroke.Methods This study was a case control study.A total of 240 stroke inpatients admitted to the Department of Neurology of Luoyang Central Hospital from January 2023 to August 2023 were selected,and they were divided into the post-stroke depression group(PSD group,76 cases)and the non depression group(NPSD group,130 cases)according to Hamilton depression scale score.The PSD group was further divided into mild,moderate and severe subgroups according to transcranial ultrasound(TCS)examination,and the imaging characteristics of the three groups were compared.Results There was a significant difference in the positive rate of raphe nucleus(BR)between the PSD group and the NPSD group(P<0.05),but there was no significant difference in the positive rate of substantia nigra(SN)and the third ventricle(V3)widening rate between the two groups(P>0.05).There was no significant difference in the proportion of BR positive,Sn positive and V3 widening among the three subgroups(P>0.05).The sensitivity,specificity,accuracy,positive predictive value and negative predictive value of BR positive for the diagnosis of PSD were 69.7%(53/76),76.9%(100/130),74.3%(153/206),63.9%(53/83)and 81.3%(100/123),respectively.Results of Spearman correlation analysis showed that there was no correlation between BR positive and the degree of depression(r=0.11,P=0.198).Conclusions BR positive has certain diagnostic efficacy for PSD,and has no correlation with the degree of depression.

关 键 词：脑卒中 抑郁 经颅超声 中缝核 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学]