盐酸埃克替尼片靶向治疗对非小细胞肺癌患者血清肿瘤标志物水平的影响  

Influence of icotinib hydrochloride tablets targeted therapy on levels of tumor markers in patients with non-small cell lung cancer

作　　者：董利[1] Dong Li(Department of Oncology I,Puyang People’s Hospital,Puyang 457000,China)

机构地区：[1]河南省濮阳市人民医院肿瘤一科,濮阳457000

出　　处：《中国实用医刊》2024年第5期91-94,共4页Chinese Journal of Practical Medicine

摘　　要：目的分析盐酸埃克替尼片靶向治疗对非小细胞肺癌(NSCLC)患者血清肿瘤标志物水平的影响。方法随机对照研究。抽取2019年2月至2022年1月濮阳市人民医院收治的NSCLC患者90例,按随机数字表法分为化疗组和靶向治疗组,每组45例。化疗组采用化疗治疗,靶向治疗组采用盐酸埃克替尼片靶向治疗。比较两组临床疗效,比较两组治疗前后血清炎症因子[超敏C反应蛋白(hs-CRP)、白细胞介素-8(IL-8)]水平、血清肿瘤标志物[癌胚抗原(CEA)、细胞角蛋白19片段抗原21-1(CYFRA21-1)、糖类抗原125(CA125)]水平和生活质量[肺癌患者生活质量测定量表(FACT-L)评分],比较两组治疗期间不良反应发生率。结果靶向治疗组总有效率(73.33%,33/45)高于化疗组(53.33%,24/45),P<0.05。治疗后,靶向治疗组hs-CRP、IL-8水平低于化疗组(P<0.05);靶向治疗组CEA、CYFRA21-1、CA125水平低于化疗组(P<0.05);靶向治疗组FACT-L评分高于化疗组(P<0.05);靶向治疗组不良反应发生率(13.33%,6/45)低于化疗组15例(33.33%,15/45),P<0.05。结论盐酸埃克替尼片靶向治疗对NSCLC患者疗效显著,能明显减轻机体炎症反应,改善肿瘤标志物水平,提升患者生活质量,减少血小板降低、脱发等不良反应。Objective To analyze the influence of icotinib hydrochloride tablets targeted therapy on levels of tumor markers in patients with non-small cell lung cancer(NSCLC).Methods A total of 90 patients with NSCLC admitted to Puyang People’s Hospital from February 2019 to January 2022 were selected for the randomized controlled study.And they were divided into the chemotherapy group and the targeted therapy group using a random number table method,with 45 cases in each group.The chemotherapy group was treated by chemotherapy,and the targeted therapy group was treated with icotinib hydrochloride tablets.The clinical efficacy of the two groups were compared.The levels of serum inflammatory factors,including hypersensitivity C-reactive protein(hs-CRP)and interleukin-8(IL-8),levels of serum tumor markers,including carcinoembryonic antigen(CEA),cytokeratin fragment antigen21-1(CYFRA21-1)and carbohydrate antigen 125(CA125),and quality of life evaluated by functional assessment of cancer therapy-lung(FACT-L)were compared between two groups before and after treatment.The incidence of adverse reactions during treatment of the two groups were compared.Results The total effective rate of the targeted therapy group(73.33%,33/45)was higher than that of the chemotherapy group(53.33%,24/45),P<0.05.After treatment,the levels of hs-CRP and IL-8 in the targeted therapy group were lower than those in the chemotherapy group(P<0.05).The levels of CEA,CYFRA21-1 and CA125 in the targeted therapy group were lower than those in the chemotherapy group after treatment(P<0.05).The FACT-L score in the targeted therapy group was higher than that in the chemotherapy group after treatment(P<0.05).The incidence of adverse reactions in the targeted therapy group(13.33%,6/45)was lower than that in the chemotherapy group(33.33%,15/45),P<0.05.Conclusions The targeted therapy with icotinib hydrochloride tablets is effective for patients with NSCLC,which can significantly reduce the inflammatory response,improve the level of tumor markers,promote the qualit

关 键 词：非小细胞肺癌 盐酸埃克替尼片 靶向治疗 肿瘤标志物 

分 类 号：R734.2[医药卫生—肿瘤]