GLUT1靶向型中药活性成分纳米递送系统的研究进展  

GLUT1-targeted Nano-delivery System for Active Ingredients of Traditional Chinese Medicine:A Review

作　　者：朱华[1] 罗慧敏 林思 王冰冰 李金薇 许立拔 张淼[1,3] 谢凤凤 陈龙 李梅林[1] 陆璐 ZHU Hua;LUO Huimin;LIN Si;WANG Bingbing;LI Jinwei;XU Liba;ZHANG Miao;XIE Fengfeng;CHEN Long;LI Meilin;LU Lu(Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine,Guangxi Collaborative Innovation Center of Zhuang and Yao Ethnic Medicine,Guangxi Zhuang Autonomous Region Ethnic Medicine Resources and Application Research Center of Engineering,Guangxi University of Chinese Medicine,Nanning 530200,China;The Second Affiliated Hospital of Guangxi Medical University,Nanning 530007,China;Guangxi Minzu University,Nanning 530006;University of Vigo,Vigo 36310,Spain)

机构地区：[1]广西中医药大学广西壮瑶药重点实验室,广西壮瑶药协同创新中心,广西壮族自治区民族药资源与应用工程研究中心,南宁530200 [2]广西医科大学第二附属医院,南宁530007 [3]广西民族大学,南宁530006 [4]维戈大学,庞特维德拉维戈36310

出　　处：《中国实验方剂学杂志》2024年第12期270-280,共11页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广西科技基地和人才专项(桂科AD21238031);广西重点研发计划项目(桂科AB21196016);广西壮瑶药重点实验室项目(桂科基字[2014]32号);壮瑶药协同创新中心项目(桂教科研[2014]13号);广西壮族自治区民族药资源与应用工程研究中心项目(桂发改高技函[2020]2605号);国家自然科学基金项目(82060695);广西一流学科中药学项目(桂教科研[2022]1号)。

摘　　要：肿瘤细胞在缺氧条件下利用糖酵解为其提供物质与能量,满足快速生长和增殖的能量需求,即“Warburg效应”。即使在有氧条件下,肿瘤细胞也主要依靠糖酵解提供能量。因此,参与葡萄糖代谢过程中的葡萄糖转运蛋白1(GLUT1)在肿瘤发生、发展及耐药中发挥着重要作用,被认为是恶性肿瘤治疗的重要靶点之一。近年来,肿瘤糖代谢方面的研究逐渐成为热点。已有研究表明,多种因子参与对肿瘤能量代谢的调控,其中尤以GLUT1的作用最为关键。该文综述了GLUT1靶向型中药活性成分纳米递送系统在肿瘤治疗中的最新研究进展,旨在揭示GLUT1靶向型中药活性成分纳米递送系统在化疗药物递送的可行性和有效性。GLUT1靶向型中药活性成分纳米递送系统可以克服传统靶向策略及高渗透长滞留(EPR)效应的瓶颈。综上所述,GLUT1靶向型中药活性成分纳米递送系统为肿瘤的靶向治疗提供了新的策略,并在肿瘤的预防和治疗中具有广阔的应用前景。Tumor cells use glycolysis to provide material and energy under hypoxic conditions to meet the energy requirements for rapid growth and proliferation,i.e.the"Warburg effect".Even under aerobic conditions,tumor cells mainly rely on glycolysis to provide energy.Therefore,glucose transporter protein 1(GLUT1),which is involved in the process of glucose metabolism,plays an important role in tumorigenesis,development,and drug resistance,and is considered one of the important targets in the treatment of malignant tumors.In recent years,research on tumor glucose metabolism has gradually become a hot spot.It has been shown that various factors are involved in the regulation of tumor energy metabolism,among which the role of GLUT1 is the most critical.In this article,the author reviewed the latest research progress of GLUT1-targeted traditional Chinese medicine active ingredient nano-delivery system in tumor therapy,aiming to reveal the feasibility and effectiveness of GLUT1-targeted traditional Chinese medicine active ingredient nano-delivery system in the delivery of chemotherapeutic drugs.The GLUT1-targeted TCM active ingredient nano-delivery system can overcome the bottleneck of the traditional targeting strategy as well as the highpermeability long retention effect(EPR effect).In summary,the authors believe that the GLUT1-targeted TCM active ingredient nano-delivery system also provides a new strategy for tumor targeting and has a broad application prospect in tumor prevention and treatment.

关 键 词：葡萄糖转运蛋白1(GLUT1) 靶向 药物递送系统 Warburg效应 肿瘤微环境 高渗透长滞留效应 中医药 

分 类 号：R22[医药卫生—中医基础理论] R28[医药卫生—中医学] R943[文化科学—图书馆学] G254