Cu-catalyzed regioselective diborylation of 1,3-enynes for the efficient synthesis of 1,4-diborylated allenes  

作　　者：Wujun Jian Mong-Feng Chiou Yajun Li Hongli Bao Song Yang 

机构地区：[1]National Key Laboratory of Green Pesticide,Key Laboratory of Green Pesticide and Agricultural Bioengineering,Ministry of Education,Center for R&D of Fine Chemicals of Guizhou University,Guiyang 550025,China [2]Strait Institute of Flexible Electronics(SIFE,Future Technologies),Fujian Normal University,Fuzhou 350117,China [3]Key Laboratory of Coal to Ethylene Glycol and Its Related Technology,State Key Laboratory of Structural Chemistry,Fujian Institute of Research on the Structure of Matter,University of Chinese Academy of Sciences,Fuzhou 350002,China

出　　处：《Chinese Chemical Letters》2024年第5期141-144,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(NSFC,Nos.22001251,21922112,and 22225107);the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB20000000);National Key R&D Program of China(No.2017YFA0700103);the Guizhou Provincial S&T Project(No.2018[4007]).

摘　　要：Borylation of 1,3-enynes with bis(boronate)compounds often ends up with the formation of hydroborylated products,leaving the diborylation of 1,3-enynes for the formation of 1,4-diborylated allenes to be challenging.Herein,a copper-catalyzed chemo-,regio-,and stereo-selective diborylation of 1,3-enynes for the efficient construction of 1,4-diborylated allenes under base-free conditions was reported.A wide range of 1,3-enynes bearing various functional groups can participant in the reaction and afforded the corresponding 1,4-diborylated allenes in good to excellent yields,which was enabled by the protocol of Bpin to BF3K conversion.the borylcopper species was supposed to selectively attack the C-C triple bond of the 1,3-enynes.

关 键 词：Copper catalysis REGIOSELECTIVE 1 3-Enynes BORYLATION ALLENES 

分 类 号：TQ263.1[化学工程—有机化工]