尤瑞克林治疗脑梗死患者的效果及对脑血流、神经损伤的影响  

Effect of Urinary Kallidinogenase in Patients with Cerebral Infarction and the Influence on Cerebral Blood Flow and Nerve Injury

作　　者：唐瑾[1] TANG Jin(Sanming Integrated Chinese and Western Medicine Hospital,Sanming 365001,China)

机构地区：[1]三明市中西医结合医院,福建三明365001

出　　处：《中外医学研究》2024年第14期31-34,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究尤瑞克林在脑梗死患者中的应用效果及对脑血流、神经损伤的影响。方法:选择2020年1月—2022年1月三明市中西医结合医院收治的80例脑梗死患者作为研究对象,依据随机数表法分为两组,各40例。对照组进行常规脑梗死治疗,观察组则在对照组治疗措施的基础上加用尤瑞克林进行治疗。比较两组的临床总有效率、治疗前后的神经功能缺损程度[改良爱丁堡-斯堪的纳维亚(MESSS)评分]、脑血流指标(大脑前动脉、中动脉及后动脉血流速)及神经损伤相关血液指标[中枢神经特异蛋白(S100β)、神经元特异性烯醇化酶(NSE)及一氧化氮(NO)]。结果:观察组临床总有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗前,两组MESSS评分、脑血流指标及神经损伤相关血液指标比较,差异无统计学意义(P>0.05);治疗1周及2周后,观察组MESSS评分优于对照组,差异有统计学意义(P<0.05);治疗1周及2周后,两组的脑血流指标、神经损伤相关血液指标显著低于治疗前,且观察组显著低于对照组,差异有统计学意义(P<0.05)。结论:尤瑞克林在脑梗死患者中的应用效果较好,且可显著改善患者的脑血流及控制神经损伤。Objective:To explore the effect of Urinary Kallidinogenase in patients with cerebral infarction and the influence on cerebral blood flow and nerve injury.Method:A total of 80 patients with cerebral infarction admitted to Sanming Integrated Traditional Chinese and Western Medicine Hospital from January 2020 to January 2022 were selected as the study objects and divided into two groups according to random number table method,with 40 patients in each group.The control group was treated with conventional cerebral infarction,and the observation group was treated with Urinary Kallidinogenase on the basis of the control group.The total clinical response rate,the degree of neurological impairment before and after treatment[modified Edinburgh-Scandinavia stroke scale(MESSS)score],cerebral blood flow(anterior,middle,and posterior cerebral artery blood flow rate),and nerve injury-related blood indicators[central nerve specific protein(S100β),neuron-specific enolase(NSE)and nitric oxide(NO)]were compared between the two groups.Result:The total clinical effective rate of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in MESSS score,cerebral blood flow index and blood index related to nerve injury between two groups(P>0.05).After 1 week and 2 weeks of treatment,the MESSS score of observation group was better than that of control group,and the difference was statistically significant(P<0.05).After 1 week and 2 weeks of treatment,cerebral blood flow indexes and nerve injection-related blood indexes in two groups were significantly lower than those before treatment,and which in observation group were significantly lower than those in control group,the differences were statistically significant(P<0.05).Conclusion:Urinary Kallidinogenase has a good effect in patients with cerebral infarction,and can significantly improve cerebral blood flow and control nerve damage.

关 键 词：尤瑞克林 脑梗死 应用效果 脑血流 神经损伤 

分 类 号：R743.33[医药卫生—神经病学与精神病学]