一氧化氮参与癫痫发生的作用机制  

Mechanism of Nitric Oxide Involved in the Occurrence of Epilepsy

作　　者：王天野 王辉[1] WANG Tianye;WANG Hui(The First Affiliated Hospital of Soochow University,Suzhou 215006,China;不详)

机构地区：[1]苏州大学附属第一医院,江苏苏州215006

出　　处：《中外医学研究》2024年第15期169-174,共6页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：癫痫是由于脑神经元异常放电导致的慢性脑部疾病,其特征为反复性、发作性及短暂性中枢神经系统功能失常,不仅可诱发偏头痛、焦虑症等疾病,还能导致患者发生心理社会功能障碍,严重影响患者身心健康。癫痫致病因素多且复杂,但其致病机制目前尚未完全明确,可能与脑神经元异常放电和大脑皮层异常活动有关。癫痫治疗周期长、难度大,对药物难治性癫痫和全身性强直性癫痫发作等效果欠佳。一氧化氮(NO)作为一种双原子气体,广泛存在于人体中,可参与调节人体基础活动。NO与癫痫发作呈明显相关性,具有双向调节作用,故NO可用于治疗癫痫,但在治疗过程中可能出现不良反应,其临床效果有待进一步优化。本文从NO与癫痫发病机制的联系进行综述,以期为临床诊治提供新的思路。Epilepsy is a chronic brain disease caused by abnormal discharge of brain neurons,which is characterized by recurrent,episodic and transient central nervous system dysfunction,which can not only induce migraines,anxiety disorders and other diseases,but also lead to psychological and social dysfunction in patients,seriously affecting the physical and mental health of patients.The pathogenic factors of epilepsy are many and complex,but its pathogenic mechanism has not been fully clarified,which may be related to abnormal discharge of brain neurons and abnormal activity of cerebral cortex.The treatment period of epilepsy is long and difficult,and the effect is not good for drug-resistant epilepsy and generalized tonic epilepsy.Nitric oxide(NO),as a diatomic gas,widely exists in the human body and can be involved in regulating the basic activities of the human body.NO is obviously correlated with epilepsy and has a bidirectional regulatory effect,so NO can be used to treat epilepsy,but adverse reactions may occur in the treatment process,and its clinical effect needs to be further optimized.This article reviewed the relationship between NO and the pathogenesis of epilepsy in order to provide new ideas for clinical diagnosis and treatment.

关 键 词：一氧化氮 癫痫 发病机制 研究进展 

分 类 号：R742.1[医药卫生—神经病学与精神病学]