Iridoids modulate inflammation in diabetic kidney disease: A review  

作　　者：Tong-yi Zhou Na Tian Liu Li Rong Yu 

机构地区：[1]The First Clinical College of Chinese Medicine,Hunan University of Chinese Medicine,Changsha 410208,Hunan Province,China [2]Hunan Provincial Key Laboratory of Translational Research in Traditional Chinese Medicine Prescriptions and Zheng,Changsha 410208,Hunan Province,China

出　　处：《Journal of Integrative Medicine》2024年第3期210-222,共13页结合医学学报（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China (No.82074400);key projects supported by the National Natural Science Foundation of China and Joint Fund for Regional Innovation and Development (No.U21A20411)。

摘　　要：In recent years,preclinical research on diabetic kidney disease (DKD) has surged to the forefront of scientific and clinical attention.DKD has become a pervasive complication of type 2 diabetes.Given the complexity of its etiology and pathological mechanisms,current interventions,including drugs,dietary modifications,exercise,hypoglycemic treatments and lipid-lowering methods,often fall short in achieving desired therapeutic outcomes.Iridoids,primarily derived from the potent components of traditional herbs,have been the subject of long-standing research.Preclinical data suggest that iridoids possess notable renal protective properties;however,there has been no summary of the research on their efficacy in the management and treatment of DKD.This article consolidates findings from in vivo and in vitro research on iridoids in the context of DKD and highlights their shared anti-inflammatory activities in treating this condition.Additionally,it explores how certain iridoid components modify their chemical structures through the regulation of intestinal flora,potentially bolstering their therapeutic effects.This review provides a focused examination of the mechanisms through which iridoids may prevent or treat DKD,offering valuable insights for future research endeavors.

关 键 词：Diabetic kidney disease IRIDOIDS Gut-kidney axis Traditional Chinese medicine monomer INFLAMMATION 

分 类 号：R58[医药卫生—内分泌]