A Comprehensive Study of the Association between LEPR Gene rs1137101 Variant and Risk of Digestive System Cancers  

作　　者：HU Wei Qiong ZHOU Wei Guang ZHOU Guang Wei LIAO Jia Xi SHI Jia Xing XIE FengYang LI Shou Heng WANG Yong FENG Xian Hong GU Xiu Li CHEN Bi Feng 

机构地区：[1]Department of Biological Science and Technology,School of Chemistry,Chemical Engineering and Life Sciences,Wuhan University of Technology,Wuhan 430070,Hubei,China [2]Institute of WUT-AMU,Wuhan University of Technology,Wuhan 430070,Hubei,China [3]Department of Clinical Laboratory,Wuhan Xinzhou District People’s Hospital,Wuhan 430499,Hubei,China [4]Department of Reproductive Genetics,Wuhan Huake Reproductive Hospital,Wuhan 430013,Hubei,China

出　　处：《Biomedical and Environmental Sciences》2024年第5期445-456,共12页生物医学与环境科学（英文版）

基　　金：supported by the Fundamental Research Funds for the Central Universities(WUT:2020IB029)。

摘　　要：Objective The leptin receptor,encoded by the LEPR gene,is involved in tumorigenesis.A potential functional variant of LEPR,rs1137101(Gln223Arg),has been extensively investigated for its contribution to the risk of digestive system(DS)cancers,but results remain conflicting rather than conclusive.Here,we performed a case–control study and subsequent meta-analysis to examine the association between rs1137101 and DS cancer risk.Methods A total of 1,727 patients with cancer(gastric/liver/colorectal:460/480/787)and 800 healthy controls were recruited.Genotyping of rs1137101 was conducted using a polymerase chain reactionrestriction fragment length polymorphism(PCR-RFLP)assay and confirmed using Sanger sequencing.Twenty-four eligible studies were included in the meta-analysis.Results After Bonferroni correction,the case–control study revealed that rs1137101 was significantly associated with the risk of liver cancer in the Hubei Chinese population.The meta-analysis suggested that rs1137101 is significantly associated with the risk of overall DS,gastric,and liver cancer in the Chinese population.Conclusion The LEPR rs1137101 variant may be a genetic biomarker for susceptibility to DS cancers(especially liver and gastric cancer)in the Chinese population.

关 键 词：LEPR gene rs1137101 Digestive system cancers Genetic susceptibility META-ANALYSIS 

分 类 号：R735[医药卫生—肿瘤]