Association of Human Whole-blood NAD+Levels with Nabothian Cyst  

作　　者：XU Ling WANG Yue Xuan WANG Wei FAN Xue CHEN Xue Yu ZHOU Tian Yun LIU Yu He YU Ye YANG Fan JU Zhen Yu ZHOU Yong WANG Deng Liang 

机构地区：[1]Clinical Research Institute,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China [2]NHC Key Lab of Reproduction Regulation,Shanghai Engineering Research Center of Reproductive Health Drugs and Devices,Shanghai Institute for Biomedical and Pharmaceutical Technologies,Shanghai 200237,China [3]Department of Applied Statistics,Johannes Kepler University Linz,Linz 4040,Austria [4]Hematology Center,Beijing Key Laboratory of Pediatric Hematology Oncology,National Key Discipline of Pediatrics(Capital Medical University),Key Laboratory of Major Diseases in Children,Ministry of Education,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing 100045,China [5]Department of Biostatistics,School of Public Health,Cheeloo College of Medicine,Shandong University,Jinan 250012,Shandong,China [6]Clinical Medicine,School of Basic Medicine,Shanghai Medical College Fudan University,Shanghai 200032,China [7]Department of Biochemistry and Molecular Biology,Hengyang Medical School,University of South China,Hengyang 421001,Hunan,China [8]Administrative Office,Total Quality Management Office,Total Quality Management Institute,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China [9]The First Affiliated Hospital of Jinan University,Institute of Aging and Regenerative Medicine,Jinan University,Jinan 510632,Guangzhou,China [10]Department of Scientific Research,The First Affiliated Hospital of Huzhou University,Huzhou 313000,Zhejiang,China [11]Department of Neurosurgery,Neurosurgery Research Institute,The First Affiliated Hospital,Fujian Medical University,Fuzhou 350005,Fujian,China [12]Department of Neurosurgery,Binhai Branch of National Regional Medical Center,The First Affiliated Hospital,Fujian Medical University,Fuzhou 350209,Fujian,China [13]Fujian Provincial Institutes of Brain Disorders and Brain Sciences,The First Affiliated Hospital,Fujian Medical University,Fuzhou 350005,Fujian,China [14]Fujian Provi

出　　处：《Biomedical and Environmental Sciences》2024年第5期471-478,共8页生物医学与环境科学（英文版）

基　　金：supported by grants from the NSFC-Regional Innovation and Development Joint Fund(No.U22A20364);the National Key R&D Program of China(No.2021YFC2500500);the National Natural Science Foundation of China(No.81973112,No.92049302)。

摘　　要：Objective Little is known about the association between whole-blood nicotinamide adenine dinucleotide(NAD^(+))levels and nabothian cysts.This study aimed to assess the association between NAD^(+)levels and nabothian cysts in healthy Chinese women.Methods Multivariate logistic regression analysis was performed to analyze the association between NAD^(+)levels and nabothian cysts.Results The mean age was 43.0±11.5 years,and the mean level of NAD^(+)was 31.3±5.3μmol/L.Nabothian cysts occurred in 184(27.7%)participants,with single and multiple cysts in 100(15.0%)and84(12.6%)participants,respectively.The total nabothian cyst prevalence gradually decreased from37.4%to 21.6%from Q1 to Q4 of NAD^(+)and the prevalence of single and multiple nabothian cysts also decreased across the NAD^(+)quartiles.As compared with the highest NAD^(+)quartile(≥34.4μmol/L),the adjusted odds ratios with 95%confidence interval of the NAD^(+)Q1 was 1.89(1.14–3.14)for total nabothian cysts.The risk of total and single nabothian cysts linearly decreased with increasing NAD^(+)levels,while the risk of multiple nabothian cysts decreased more rapidly at NAD^(+)levels of 28.0 to35.0μmol/L.Conclusion:Low NAD^(+)levels were associated with an increased risk of total and multiple nabothian cysts.

关 键 词：Nicotinamide adenine dinucleotide Nabothian cyst FEMALE Risk factor 

分 类 号：R737.31[医药卫生—肿瘤]