Role of marine natural products in the development of antiviral agents against SARS‑CoV‑2:potential and prospects  

作　　者：D.P.Nagahawatta N.M.Liyanage Thilina U.Jayawardena H.H.A.C.K.Jayawardhana Seong‑Hun Jeong Hyung‑Jun Kwon You‑Jin Jeon 

机构地区：[1]Department of Marine Life Sciences,Jeju National University,Jeju 690-756,Republic of Korea [2]Department of Chemistry,Biochemistry and Physics,Universitédu QuébecàTrois-Rivières,Trois-Rivières,QC G8Z 4M3,Canada [3]Marine Science Institute,Jeju National University,Jeju 63333,Republic of Korea [4]Functional Biomaterial Research Center,Korea Research Institute of Bioscience and Biotechnology,Jeongeup-si,Republic of Korea

出　　处：《Marine Life Science & Technology》2024年第2期280-297,共18页海洋生命科学与技术（英文）

基　　金：part of the project“Develop-ment of functional food products with natural materials derived from marine resources(no.20170285)”,funded by the Ministry of Oceans and Fisheries,Korea.

摘　　要：A novel coronavirus,known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has surfaced and caused global concern owing to its ferocity.SARS-CoV-2 is the causative agent of coronavirus disease 2019;however,it was only discovered at the end of the year and was considered a pandemic by the World Health Organization.Therefore,the develop-ment of novel potent inhibitors against SARS-CoV-2 and future outbreaks is urgently required.Numerous naturally occurring bioactive substances have been studied in the clinical setting for diverse disorders.The intricate infection and replication mechanism of SARS-CoV-2 offers diverse therapeutic drug targets for developing antiviral medicines by employing natural products that are safer than synthetic compounds.Marine natural products(MNPs)have received increased attention in the development of novel drugs owing to their high diversity and availability.Therefore,this review article investigates the infection and replication mechanisms,including the function of the SARS-CoV-2 genome and structure.Furthermore,we highlighted anti-SARS-CoV-2 therapeutic intervention efforts utilizing MNPs and predicted SARS-CoV-2 inhibitor design.

关 键 词：SARS-CoV-2 Marine natural products Drug targets INHIBITORS 

分 类 号：R373[医药卫生—病原生物学]