骨原发淋巴瘤患者的临床病理特征及预后分析  

Clinicopathological characteristics and prognosis of primary bone lymphomas

作　　者：郭国宁 陈景畅 彭玲 王长松 GUO Guo-ning;CHEN Jing-chang;PENG Ling;WANG Chang-song(Department of Orthopaedics,Kweichou Moutai Hospital,Renhuai,Guizhou,564500,China)

机构地区：[1]贵州茅台医院骨科,仁怀564500 [2]河南科技大学护理学院,洛阳471031 [3]中国人民解放军联勤保障部队第九八九医院特诊科,洛阳471031 [4]中国人民解放军联勤保障部队第九八九医院病理科,洛阳471031

出　　处：《中国骨与关节杂志》2024年第5期331-335,共5页Chinese Journal of Bone and Joint

基　　金：贵州省科技计划项目(LC2022-034);贵州茅台医院2022年度科研与人才培养(MTyk2022-21);遵义市科技计划项目(HZ 2020-259)。

摘　　要：目的结合国内外文献探讨骨原发性淋巴瘤(primary bone lymphomas,PBLs)的临床病理学特征、诊断、鉴别诊断及预后。方法回顾性分析10例PBLs患者的临床表现、病理形态学特征、免疫表型、治疗及预后的相关资料。结果PBLs多发生于中年男性,70%(7/10)累及单骨,30%(3/10)累及多骨。患者无特异性临床表现,影像学表现为溶骨性病变、病理性骨折等。形态学上瘤细胞弥漫分布,细胞体积较大,大小一致,核圆形,可见病理性核分裂象。瘤细胞表达B淋巴细胞标记,而不表达T淋巴细胞标记。结论PBLs是原发于骨的罕见淋巴瘤,组织学类型以弥漫大B细胞淋巴瘤为主,临床依赖于病理诊断,联合治疗预后较好。Objective To study the clinicopathological features,diagnosis,differential diagnosis and prognosis of bone primary lymphoma.Methods The clinical manifestations,pathologic-morphological features,immunophenotype,treatment and prognosis of 10 patients with PBLs were retrospectively analyzed.Results PBLs mostly occurred in middle-aged men.Most involved single bone(70%,7/10),and a few involved multiple bones(30%,3/10).The patients had no specific clinical manifestation,and the imaging manifestations included osteolytic lesions and pathological fractures.Morphologically,the tumor cells were diffusely distributed.The cell volume was large,the size was consistent,the nucleus was round,and pathological nuclear division was visible.Tumor cells expressed B lymphocyte markers but not T lymphocyte markers.Conclusions PBLs is a rare lymphomas originating from bone,and the histological type is mainly DLBCL.Accurate diagnosis is based on the pathological and immunohistochemistry methods,with good prognosis by combination therapy.

关 键 词：淋巴瘤 骨肿瘤 病理学 外科 免疫表型分型 预后 骨原发性淋巴瘤 

分 类 号：R73[医药卫生—肿瘤]