体位性低血压对多系统萎缩患者认知功能障碍的影响研究进展  

Recent advance in influence of orthostatic hypotension in cognitive dysfunction in patients with multiple system atrophy

作　　者：王新 康佳 海日罕 潘竞[1] Wang Xin;Kang Jia;Hairihan;Pan Jing(Department of Neurology,Second Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010020,China)

机构地区：[1]内蒙古医科大学第二附属医院神经内科,呼和浩特010020

出　　处：《中华神经医学杂志》2024年第4期409-412,共4页Chinese Journal of Neuromedicine

基　　金：内蒙古自治区自然科学基金(2020MS08138);内蒙古医科大学青年项目(YKD2023QN005);内蒙古医科大学学科建设项目(YKD2023XK008)。

摘　　要：体位性低血压(OH)是多系统萎缩(MSA)患者最突出的自主神经功能障碍表现。虽然疾病早期出现痴呆和认知波动仍是MSA的排除标准,但目前越来越多的研究却发现轻度认知功能障碍(MCI)在MSA中普遍存在。鉴于帕金森病(PD)患者中OH可因引起反复脑灌注不足致其罹患认知功能障碍风险增加,而OH在MSA患者中较PD患者出现的更早、更普遍、更严重,因此,深入研究OH是否可以作为改善MSA患者认知功能障碍的调节因子,以及二者间是因果关系还是有着共同的神经生物学基础,具有着重要意义。本文现围绕MSA患者的OH在其认知功能障碍发生发展中的可能影响展开综述,并总结存在的问题及展望未来的研究方向,以期加强临床医生对MSA患者OH和认知功能障碍的认识。Orthostatic hypotension(OH)is the most prominent autonomic neurodysfunction in patients with multiple system atrophy(MSA).Dementia and cognitive fluctuations at early course of the disease remain the exclusion criteria for MSA,however,increased studies have indicated that mild cognitive impairment is prevalent in MSA.OH is associated with an increased risk of cognitive dysfunction in patients with Parkinson's disease(PD)due to recurrent cerebral hypoperfusion,and earlier,more prevalent and more severe OH occurs in MSA patients than that in PD patients;therefore,could OH serve as a modifier to improve cognitive dysfunction in MSA patients?Do the two interact as both cause and effect,or do they share a common neurobiological basis?This paper reviews the influence of OH in cognitive dysfunction in MSA patients,and summarizes the existing problems and looks forward to future research directions,with a view to enhance clinicians'understanding of OH and cognitive dysfunction in MSA patients.

关 键 词：多系统萎缩 体位性低血压 认知功能障碍 

分 类 号：R749.1[医药卫生—神经病学与精神病学] R741[医药卫生—临床医学]