血清SCC-Ag、CK19、CA724及VEGF表达水平对宫颈癌患者TACE术后预后价值分析  

Theprognostic value of serum expression levels of SCC-Ag,CK19,CA724 and VEGF in patients with cervical cancer after TACEsurgery

作　　者：马波 王钊华[2] 王海燕 Ma Bo;Wang Zhaohua;Wang Haiyan(Department of Intervention Vascular Surgery,Cangzhou Peoples Hospital,Cangzhou Hebei 061000;Laboratory,Shjiazhuang Fourth Hospital,Shijiazhuang Hebei 050000;Department of Oncology,982 Hospital,Joint Service Support Department of the People's Liberation Army,Tangshan Hebei 063000,P.R.China)

机构地区：[1]沧州市人民医院介入血管外科,河北沧州061000 [2]石家庄市第四医院检验科,河北石家庄050000 [3]解放军联勤保障部第九八二医院肿瘤科,河北唐山063000

出　　处：《中国计划生育和妇产科》2024年第5期97-100,110,I0001,共6页Chinese Journal of Family Planning & Gynecotokology

基　　金：2020年度河北省医学科学研究重点课题计划(项目编号:20200152)。

摘　　要：目的探讨血清鳞状细胞癌抗原(SCC-Ag)、细胞角蛋白19(CK19)、肿瘤相关糖类抗原724(CA724)和血管内皮生长因子(VEGF)对宫颈癌患者动脉灌注化疗栓塞(TACE)术后预后的价值分析。方法收集石家庄市第四医院2019年10月至2021年10月收治的160例行TACE术的宫颈癌患者资料,根据预后情况分为预后良好组(125例)和预后不良组(35例),统计患者年龄、肿瘤直径、病理类型、肌层浸润情况等一般临床资料以及血清中SCC-Ag、CK19、CA724和VEGF水平进行单因素分析,将有统计学意义的自变量纳入Logistic回归模型分析影响预后的因素,通过ROC曲线分析其对宫颈癌患者预后的预测价值。结果21.88%患者预后不良。预后不良组宫颈癌患者血清中SCC-Ag、CK19、CA724和VEGF的表达水平高于预后良好组(P<0.05)。Logistic回归分析表明:宫颈癌患者血清中SCC-Ag、CK19、CA724和VEGF水平升高是影响TACE术后预后的独立危险因素(P<0.05);ROC曲线表明:SCC-Ag、CK19、CA724及VEGF对宫颈癌患者TACE术后预后不良的最佳截断点分别为27.65 ng/mL、17.39 ng/mL、11.84 IU/mL、292.92 pg/mL,AUC分别为0.745、0.839、0.875、0.764,四者联合检测为0.970。结论SCC-Ag、CK19、CA724及VEGF水平是宫颈癌患者TACE术后预后不良的影响因素,对患者预后情况具有一定的预测价值,四者联合检测预测效能最高。Objective To evaluate the prognostic value of serum squamous cell carcinoma antigen(SCC-Ag),cytokeratin 19(CK19),tumor-associated carbohydrate antigen 724(CA724)and vascular endothelial growth factor(VECF)in patients with cervical cancer after arterial infusion chemoembolization(TACE).Methods 160 patients with cervical cancer who underwent TACE surgery admitted to Shijiazhuang Fourth Hospital from October 2019 to October 2021 were collected and divided into good prognosis group(125 cases)and poor prognosis group(35 cases)according to the prognosis.The patients'general clinical data,such as age,tumor diameter,pathological type and muscular infiltration and SCC-Ag,CK19,CA724,VECF levels were collected for univariate analysis.Statistically significant independent variables were included in the Logisitc regression model to analyze the factors affecting prognosis,and the diagnostic value of independent risk factors affecting prognosis was analyzed by ROC curve.Results The prognosis of 21.88%of patients was poor.The expression levels of SCC-Ag,CK19,CA724 and VEGF in serum of cervical cancer patients in poor prognosis group were higher than those in good prognosis group(P<0.05).Logistic regression analysis showed that the elevated expression levels of SCC-Ag,CK19,CA724 and VECF in the serum of cervical cancer patients were independent risk factors for prognosis(P<0.05).ROC curve showed that:the optimal cut-ff points of SCC-Ag,CK19,CA724 and VECF for poor prognosis afer TACE surgery in cervical cancer patients were 27.65 ng/mL,17.39 ng/mL,11.84 IU/mL,292.92 pg/mL,respectively.The AUC values were 0.745,0.839,0.875,0.764,respectively,the AUC of the combined test of the four was 0.970.Conclusions The levels of SCC-Ag,CK19,CA724 and VECF are the factors affecting the poor prognosis of patients with cervical cancer after TACE surgery,and have a certain predictive value for the patients'prognosis,and the combined detection of the four has the highest predictive efficacy.

关 键 词：鳞状细胞癌抗原 细胞角蛋白19 肿瘤相关糖类抗原724 血管内皮生长因子 宫颈癌 动脉灌注化疗栓塞术 

分 类 号：R737.33[医药卫生—肿瘤]