活化白细胞黏附分子在乳腺癌中的研究进展  

Research progress of activated leukocyte adhesion molecule in breast cancer

作　　者：谢俊岭 XIE Junling(School of Public Health,North China University of Science and Technology,Tangshan 063210,China)

机构地区：[1]华北理工大学公共卫生学院,唐山063210

出　　处：《实用肿瘤学杂志》2024年第1期45-49,共5页Practical Oncology Journal

基　　金：河北省自然科学基金资助项目(编号:H2020209037)。

摘　　要：乳腺癌是全球女性最常见的肿瘤,也是导致女性死亡最主要的疾病之一。肿瘤相关标志物及治疗靶点的研究已成为肿瘤领域的一个热点话题。研究发现活化白细胞黏附分子(Activated leukocyte cell adhesion molecule,ALCAM)在乳腺癌的发生发展过程中发挥重要的作用,并且与乳腺癌患者的预后具有相关性。本文针对ALCAM的分子结构特征、ALCAM与乳腺癌临床指征及预后的相关性,以及ALCAM作为乳腺癌临床诊断及治疗靶点的研究和应用进展进行综述。Breast cancer is the most common cancer among women worldwide,and it is also one of the most important diseases that cause women′s death.The study of tumor related biomarkers and therapeutic targets has become a hot topic in the field of cancer.Studies have found that activated leukocyte cell adhesion molecule(ALCAM)plays an important role in the occurrence and development of breast cancer,and it is related to the prognosis of breast cancer patients.This article reviews the molecular characteristics of ALCAM,the correlation between ALCAM expression and breast cancer clinical feature and prognosis,and the research and application of ALCAM as a target for clinical diagnosis and treatment of breast cancer.

关 键 词：活化白细胞黏附分子 乳腺癌 肿瘤标志物 

分 类 号：R737.9[医药卫生—肿瘤]