丙戊酸盐影响成瘾药物诱导的行为敏化及其机制的研究进展  

Research progress on the influence of valproate on behavioral sensitization induced by addictive drug and its mechanism

作　　者：王利新 孙优会 黄静静 李元荣 王绪轶[1] WANC Li-xin;SUN You-hui;HUANG Jing-jing;LI Yuan-rong;WANG Xu-yi(Institute of Mental Health,Central South University,Changsha 410011,China;People's Hospictal of Jiangxi Province,Nanchang 330006,China)

机构地区：[1]中南大学精神卫生研究所,长沙410011 [2]江西省人民医院,南昌330006

出　　处：《中国药物依赖性杂志》2024年第2期116-121,共6页Chinese Journal of Drug Dependence

摘　　要：丙戊酸盐(valproate, VPA)是临床治疗癫痫、双相情感障碍及偏头痛的有效药物。近年来研究发现,VPA可以影响成瘾药物诱导的行为敏化的形成和表达,但其机制尚不完全清楚。本文综述了VPA对成瘾药物诱导的行为敏化的影响,并从其对糖原合酶激酶-3β(glycogen synthase kinase-3β,GSK-3β)的抑制作用、组蛋白去乙酰化酶(histone deacetylase, HDAC)的抑制作用、中枢γ-氨基丁酸(γ-aminobutyric acid, GABA)系统调节作用三方面来探讨其对行为敏化的影响机制,以期为探索药物成瘾的干预策略提供依据。Valproate(VPA)is an effective drug in the treatment of epilepsy,bipolar disorder and migraine.In recent years,it has been found that VPA can affect the formation and expression of behavioral sensitization induced by addictive drug,but its mechanism is not fully understood.In this paper,the effects of VPA on behavioral sensitization induced by addictive drugs were reviewed,and the mechanism of VPA on behavioral sensitization was discussed from three aspects:inhibition of glycogen synthase kinase-3β,inhibition of histone deacetylase,and regulation of central GABA system,which provides some basis for exploring the intervention strategy of drug addiction.

关 键 词：丙戊酸盐 成瘾 行为敏化 GABA HDAC GSK-3Β 

分 类 号：R749[医药卫生—神经病学与精神病学]