参数σ^(2)_((k·EC_(x)))与多元混合物联合作用的关系研究  

RELATIONSHIP BETWEEN PARAMETER σ^(2)_((k·EC_(x)))AND INTERACTION OF MULTI-COMPONENT MIXTURES

作　　者：王娜[1] 杨鑫悦 蔡文涛 孙嘉靖 马晓妍[3] 张豫姣 WANG Na;YANG Xinyue;CAI Wentao;SUN Jiajing;MA Xiaoyan;ZHANG Yujiao(School of Architecture and Civil Engineering,Xi'an University of Science and Technology,Xi'an 710054,China;Guangrao County Branch,Dongying Ecological and Environmental Bureau,Dongying 257000,China;School of Environmental and Municipal Engineering,Xi'an University of Architecture and Technology,Xi'an 710055,China)

机构地区：[1]西安科技大学建筑与土木工程学院,西安710054 [2]东营市生态环境局广饶县分局,山东东营257000 [3]西安建筑科技大学环境与市政工程学院,西安710055

出　　处：《环境工程》2024年第3期58-66,共9页Environmental Engineering

基　　金：国家自然科学基金项目(51708447)。

摘　　要：表征多元混合物各组分浓度效应曲线(CRC)形态差异的参数σ^(2)_((k·EC_(x)))可以预测多元混合物的联合毒性,进一步探索σ^(2)_((k·EC_(x)))与多元混合物联合作用强度和方式的关系。选取11种环境污染物,按照物质CRC的参数k·ECx的数值分为D组(相异体系)和S组(相似体系),设计18组多元混合物,借助独立作用模型(IA)和效应残差比(ERRx)模型评价混合物的联合作用。结果表明:D组混合体系易发生联合作用方式的转变;S组混合体系联合作用方式保持不变。D组中σ^(2)_((k·EC_(x)))较大的混合物不易发生联合作用方式的转变。D组混合物整体联合作用强度大于S组,各混合体系内联合作用强度与σ^(2)_((k·EC_(x)))正相关。该研究揭示了参数σ^(2)_((k·EC_(x)))与多元混合物联合作用的关系,实现了从几何角度对多元混合物联合作用的预判,为环境风险评价提供一定的理论支持。Previous studies have found that the parameter k·EC_(x) can characterize the shape of the concentration-reaction curves(CRCs),and its derived parameterσ^(2)_((k·EC_(x)))(the variance of k·ECx for each component)can predict the combined toxicity of multi-component mixtures.This study further explored the relationship betweenσ^(2)_((k·EC_(x)))and the strength and mode of joint action.Eleven environmental pollutants were divided into group D(different system)and group S(similar system)according to the value of parameter k·EC_(x).A total of 18 mixtures(11 in group D,and 7 in group S)were designed.The joint action of mixtures was evaluated by independent action model(IA)and effect residual ratio(ERRx)model.The mixed systems with different parameters k·ECx(group D in this paper)were prone to change the mode of joint action.The mixed systems with similar k·EC_(x) of each component(group S in this paper)kept the mode of interaction unchanged.In the group D,the mode of interaction of mixtures with a largerσ^(2)_((k·EC_(x)))was not easy to change.The strength of the joint action of group D was greater than that of group S overall.The strength of the interaction in every mixed system was positively correlated with theσ^(2)_((k·EC_(x))).This study revealed the relationship between theσ^(2)_((k·EC_(x)))and the joint action of multiple mixtures,and achieved the prejudgement of the joint action of multiple mixtures from a geometric perspective,which can provide certain theoretical support for the environmental risk assessment.

关 键 词：σ^(2)_((k·EC_(x))) IA 费氏弧菌 急性毒性 联合作用 

分 类 号：R73[医药卫生—肿瘤]