Cardiovascular mechanisms of thyroid hormones and heart failure:Current knowledge and perspectives  

作　　者：Viktor Culic 

机构地区：[1]Department of Cardiology and Angiology,University Hospital Centre Split,University of Split School of Medicine,Split 21000,Croatia

出　　处：《World Journal of Cardiology》2024年第5期226-230,共5页世界心脏病学杂志（英文版）（电子版）

摘　　要：A multiple hormonal imbalance that accompanies heart failure(HF)may have a significant impact on the clinical course in such patients.The non-thyroidal illness syndrome(NTIS),also referred to as euthyroid sick syndrome or low triiodothyronine syndrome,can be found in about 30%of patients with HF.NTIS represents a systemic adaptation to chronic illness that is associated with increased cardiac and overall mortality in patients with HF.While conclusions on thyroid-stimulating hormone,free triiodothyronine,total and free thyroxine are currently unresolved,serum total triiodothyronine levels and the ratio of free triiodothyronine to free thyroxine seem to provide the best correlates to the echocardiographic,laboratory and clinical parameters of disease severity.HF patients with either hyper-or hypothyroidism should be treated according to the appropriate guidelines,but the therapeutic approach to NTIS,with or without HF,is still a matter of debate.Possible treatment options include better individual titration of levothyroxine therapy,combined triiodothyronine plus thyroxine therapy and natural measures to increase triiodothyronine.Future research should further examine the cellular and tissue mechanisms of NTIS as well as new therapeutic avenues in patients with HF.

关 键 词：Heart failure Non-thyroidal illness syndrome Low triiodothyronine syndrome Therapy THYROXINE TRIIODOTHYRONINE 

分 类 号：R587.2[医药卫生—内分泌] R541.6[医药卫生—内科学]