Cetuximab combined with chemotherapy for simultaneous esophageal squamous cell carcinoma and colon adenocarcinoma:A case report  

作　　者：Xin-Xin Luo Yu-Xuan Du Qi-Qing Zhang Lin Zhang Shu-Ying Zeng Zhi-Hong Yu Peng Shen Zheng-Quan Feng 

机构地区：[1]The Second School of Clinical Medicine,Zhejiang Chinese Medical University,Hangzhou,310053,Zhejiang Province,China [2]Department of Oncology,Tongde Hospital of Zhejiang Province,Hangzhou 310012,Zhejiang Province,China [3]Department of Medical Oncology,The First Affiliated Hospital,Medical College of Zhejiang University,Hangzhou 310003,Zhejiang Province,China

出　　处：《World Journal of Clinical Cases》2024年第15期2649-2654,共6页世界临床病例杂志

摘　　要：BACKGROUND Multiple primary carcinomas(MPCs)are defined as two or more independent primary cancers that occur simultaneously or sequentially in the same individual.Synchronous MPCs are rarer than solitary cancers or metachronous MPCs.Accurate diagnoses of synchronous MPCs and the choice of treatment are critical for successful outcomes in these cases.CASE SUMMARY A 64-year-old patient presented with dysphagia,without obvious cause.A diagnosis of synchronous esophageal squamous cell carcinoma and colon adenocarcinoma with liver metastasis was confirmed based on examination and laboratory results.After multi-disciplinary consultations,combination chemotherapy(a 3-wk cycle with oxaliplatin 212 mg administered on day 1 and capecitabine 1.5 g twice daily on days 1-14)and esophageal cancer radiotherapy were initiated.Based on the results of genetic testing,we switched to a regimen of leucovorin+fluorouracil+oxaliplatin and cetuximab regimen for 8 cycles.Subsequently,capecitabine and bevacizumab were administered until the most recent follow-up,at which the tumor remained stable.CONCLUSION Successful cetuximab chemotherapy treatment provides a reference for the nonoperative and homogeneous treatment of different pathological types of synchronous MCPs.

关 键 词：Synchronous multiple primary carcinoma Esophageal squamous cell carcinoma Colon adenocarcinoma CETUXIMAB CHEMOTHERAPY Case report 

分 类 号：R735.1[医药卫生—肿瘤]