Fecal calprotectin in pediatric gastrointestinal diseases:Pros and cons  

作　　者：Mohammed Al-Beltagi Nermin Kamal Saeed Adel Salah Bediwy Reem Elbeltagi 

机构地区：[1]Department of Pediatric,Faculty of Medicine,Tanta University,Tanta 31511,Alghrabia,Egypt [2]Department of Pediatrics,University Medical Center,King Abdulla Medical City,Arabian Gulf University,Manama 26671,Manama,Bahrain [3]Department of Pediatrics,University Medical Center,Dr.Sulaiman Al Habib Medical Group,Bahrain,Manama 26671,Manama,Bahrain [4]Medical Microbiology Section,Department of Pathology,Salmaniya Medical Complex,Ministry of Health,Kingdom of Bahrain,Manama 12,Manama,Bahrain [5]Medical Microbiology Section,Department of Pathology,Irish Royal College of Surgeon,Bahrain,Busaiteen 15503,Muharraq,Bahrain [6]Department of Pulmonology,Faculty of Medicine,Tanta University,Tanta 31527,Alghrabia,Egypt [7]Department of Pulmonology,University Medical Center,King Abdulla Medical City,Arabian Gulf University,Manama 26671,Manama,Bahrain [8]Department of Pulmonology,University Medical Center,King Abdulla Medical City,Dr.Sulaiman Al Habib Medical Group,Manama 26671,Manama,Bahrain [9]Department of Medicine,The Royal College of Surgeons in Ireland-Bahrain,Busiateen 15503,Muharraq,Bahrain

出　　处：《World Journal of Clinical Pediatrics》2024年第2期198-220,共23页世界临床儿科杂志

摘　　要：BACKGROUND Fecal calprotectin is a valuable biomarker for assessing intestinal inflammation in pediatric gastrointestinal diseases.However,its role,pros,and cons in various conditions must be comprehensively elucidated.AIM To explore the role of fecal calprotectin in pediatric gastrointestinal diseases,including its advantages and limitations.METHODS A comprehensive search was conducted on PubMed,PubMed Central,Google Scholar,and other scientific research engines until February 24,2024.The review included 88 research articles,56 review articles,six metaanalyses,two systematic reviews,two consensus papers,and two letters to the editors.RESULTS Fecal calprotectin is a non-invasive marker for detecting intestinal inflammation and monitoring disease activity in pediatric conditions such as functional gastrointestinal disorders,inflammatory bowel disease,coeliac disease,coronavirus disease 2019-induced gastrointestinal disorders,gastroenteritis,and cystic fibrosis-associated intestinal pathology.However,its lack of specificity and susceptibility to various confounding factors pose challenges in interpretation.Despite these limitations,fecal calprotectin offers significant advantages in diagnosing,monitoring,and managing pediatric gastrointestinal diseases.CONCLUSION Fecal calprotectin holds promise as a valuable tool in pediatric gastroenterology,offering insights into disease activity,treatment response,and prognosis.Standardized protocols and guidelines are needed to optimize its clinical utility and mitigate interpretation challenges.Further research is warranted to address the identified limitations and enhance our understanding of fecal calprotectin in pediatric gastrointestinal diseases.

关 键 词：Fecal calprotectin Pediatric gastrointestinal diseases Functional gastrointestinal disorders Inflammatory bowel disease Coeliac disease COVID-19-induced gastrointestinal disorders Infectious gastroenteritis Cystic fibrosis 

分 类 号：R57[医药卫生—消化系统]