Early detection of pancreatic cancer  

作　　者：Francisco J Morera-Ocon 

机构地区：[1]Department of General Surgery,Hospital General de Requena,Requena 46340,Spain

出　　处：《World Journal of Clinical Cases》2024年第17期2935-2938,共4页世界临床病例杂志

摘　　要：The diagnosis of pancreatic cancer associates an appalling significance.Detection of preinvasive stage of pancreatic cancer will ameliorate the survival of this deadly disease.Premalignant lesions such as Intraductal Papillary Mucinous Neoplasms or Mucinous Cystic Neoplasms of the pancreas are detectable on imaging exams and this permits their management prior their invasive development.Pancreatic intraepithelial neoplasms(PanIN)are the most frequent precursors of pancreatic adenocarcinoma(PDAC),and its particular type PanIN high-grade represents the malignant non-invasive form of PDAC.Unfortunately,PanINs are not detectable on radiologic exams.Nevertheless,they can associate indirect imaging signs which would rise the diagnostic suspicion.When this suspicion is established,the patient will be enrolled in a follow-up strategy that includes performing of blood test and serial imaging test such as computed tomography or magnetic resonance imaging,which will cost in the best-case scenario a burden of healthcare systems,and potential mortality in the worst-case scenario when the patient underwent resection surgery,worthless when there is no moderate or high grade dysplasia in the final histopathology.This issue will be avoid having at its disposal a diagnostic technique capable of detecting high-grade PanIN lesions,such is the cytology of pancreatic juice obtained by nasopancreatic intubation.Herein,we review the possibility of detection of early malignant lesions before they become invasive PADC.

关 键 词：Early pancreatic cancer Pancreatic adenocarcinoma precursor lesions Pancreatic juice analysis PANIN High-grade pancreatic intraepithelial neoplasm Magnetic resonance cholangiopancreatography 

分 类 号：R735.9[医药卫生—肿瘤]