Dosimetric risk factors for radiation esophagitis in patients with breast cancer following regional nodal radiation  

作　　者：Mei-Chen Ji Zhi-Jia Li Ke Li Yun-Xiao Wang Bo Yang Lin-Lin Lv Ying Su Zhi-Wei Zhang Zhong-Chao Huo Qing Qi Yong-Chang Lu Zhi-Qiang Cui Yan-Bao Liu 

机构地区：[1]Oncology Center,The Affiliated Hospital of Hebei University of Engineering,Handan 056002,Hebei Province,China [2]General Surgery Department,Handan First Hospital,Handan 056002,Hebei Province,China [3]Department of Breast Surgery,The Affiliated Hospital of Hebei University of Engineering,Handan 056002,Hebei Province,China [4]School of Clinical Medicine,Hebei University of Engineering,Handan 056002,Hebei Province,China

出　　处：《World Journal of Clinical Cases》2024年第17期2995-3003,共9页世界临床病例杂志

基　　金：Supported by Handan City Science and Technology Research and Development Program,No.21422083353;The Guangdong Medical Science and Technology Research Fund,No.20221115181236662.

摘　　要：BACKGROUND Radiation esophagitis(RE)is one of the most common clinical symptoms of regional lymph node radiotherapy for breast cancer.However,there are fewer studies focusing on RE caused by hypofractionated radiotherapy(HFRT).AIM To analyze the clinical and dosimetric factors that contribute to the development of RE in patients with breast cancer treated with HFRT of regional lymph nodes.METHODS Between January and December 2022,we retrospectively analysed 64 patients with breast cancer who met our inclusion criteria underwent regional nodal intensity-modulated radiotherapy at a radiotherapy dose of 43.5 Gy/15F.RESULTS Of the 64 patients in this study,24(37.5%)did not develop RE,29(45.3%)developed grade 1 RE(G1RE),11(17.2%)developed grade 2 RE(G2RE),and none developed grade 3 RE or higher.Our univariable logistic regression analysis found G2RE to be significantly correlated with the maximum dose,mean dose,relative volume 20-40,and absolute volume(AV)20-40.Our stepwise linear regression analyses found AV30 and AV35 to be significantly associated with G2RE(P<0.001).The optimal threshold for AV30 was 2.39 mL[area under the curve(AUC):0.996;sensitivity:90.9%;specificity:91.1%].The optimal threshold for AV35 was 0.71 mL(AUC:0.932;sensitivity:90.9%;specificity:83.9%).CONCLUSION AV30 and AV35 were significantly associated with G2RE.The thresholds for AV30 and AV35 should be limited to 2.39 mL and 0.71 mL,respectively.

关 键 词：Breast cancer Dosimetric parameters Radiation esophagitis ESOPHAGITIS Hypofractionated radiotherapy 

分 类 号：R737.9[医药卫生—肿瘤]