Immune cell signatures and causal association with irritable bowel syndrome:A mendelian randomization study  

作　　者：Wei-Hao Chai Yan Ma Jia-Jia Li Fei Guo Yi-Zhan Wu Jiang-Wei Liu 

机构地区：[1]Department of Graduate School,Xinjiang Medical University,Urumqi 830000,Xinjiang Uygur Autonomous Region,China [2]Department of Anesthesiology,The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,Xinjiang Uygur Autonomous Region,China [3]Key Laboratory of Special Environmental Medicine of Xinjiang,General Hospital of Xinjiang Military Command of the PLA,Urumqi 830000,Xinjiang Uygur Autonomous Region,China [4]Department of Emergency Trauma Surgery,The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,Xinjiang Uygur Autonomous Region,China

出　　处：《World Journal of Clinical Cases》2024年第17期3094-3104,共11页世界临床病例杂志

摘　　要：BACKGROUND The mucosal barrier's immune-brain interactions,pivotal for neural development and function,are increasingly recognized for their potential causal and therapeutic relevance to irritable bowel syndrome(IBS).Prior studies linking immune inflammation with IBS have been inconsistent.To further elucidate this relationship,we conducted a Mendelian randomization(MR)analysis of 731 immune cell markers to dissect the influence of various immune phenotypes on IBS.Our goal was to deepen our understanding of the disrupted brain-gut axis in IBS and to identify novel therapeutic targets.AIM To leverage publicly available data to perform MR analysis on 731 immune cell markers and explore their impact on IBS.We aimed to uncover immunophenotypic associations with IBS that could inform future drug development and therapeutic strategies.METHODS We performed a comprehensive two-sample MR analysis to evaluate the causal relationship between immune cell markers and IBS.By utilizing genetic data from public databases,we examined the causal associations between 731 immune cell markers,encompassing median fluorescence intensity,relative cell abundance,absolute cell count,and morphological parameters,with IBS susceptibility.Sensitivity analyses were conducted to validate our findings and address potential heterogeneity and pleiotropy.RESULTS Bidirectional false discovery rate correction indicated no significant influence of IBS on immunophenotypes.However,our analysis revealed a causal impact of IBS on 30 out of 731 immune phenotypes(P<0.05).Nine immune phenotypes demonstrated a protective effect against IBS[inverse variance weighting(IVW)<0.05,odd ratio(OR)<1],while 21 others were associated with an increased risk of IBS onset(IVW≥0.05,OR≥1).CONCLUSION Our findings underscore a substantial genetic correlation between immune cell phenotypes and IBS,providing valuable insights into the pathophysiology of the condition.These results pave the way for the development of more precise biomarkers and targeted therapies for IBS.Fur

关 键 词：Irritable bowel syndrome Immunophenotypes CAUSALITY Brain-gut axis Mendelian randomization Sensitivity analysis 

分 类 号：R574[医药卫生—消化系统]