Intensive care unit-acquired weakness and mechanical ventilation:A reciprocal relationship  

作　　者：Ranjeet Kumar Sinha Sony Sinha Prateek Nishant Arvind Kumar Morya 

机构地区：[1]Department of Community Medicine,Patna Medical College,Bihar,Patna 800004,India [2]Department of Ophthalmology-Vitreo-Retina,Neuro-Ophthalmology and Oculoplasty,All India Institute of Medical Sciences,Bihar,Patna 801507,India [3]Department of Ophthalmology,ESIC Medical College,Bihar,Patna 801113,India [4]Department of Ophthalmology,All India Institute of Medical Sciences,Telangana,Hyderabad 508126,India

出　　处：《World Journal of Clinical Cases》2024年第18期3644-3647,共4页世界临床病例杂志

摘　　要：Intensive care unit-acquired weakness(ICU-AW;ICD-10 Code:G72.81)is a syndrome of generalized weakness described as clinically detectable weakness in critically ill patients with no other credible cause.The risk factors for ICU-AW include hyperglycemia,parenteral nutrition,vasoactive drugs,neuromuscular blocking agents,corticosteroids,sedatives,some antibiotics,immobilization,the disease severity,septicemia and systemic inflammatory response syndrome,multiorgan failure,prolonged mechanical ventilation(MV),high lactate levels,older age,female sex,and pre-existing systemic morbidities.There is a definite association between the duration of ICU stay and MV with ICU-AW.However,the interpretation that these are modifiable risk factors influencing ICU-AW,appears to be flawed,because the relationship between longer ICU stays and MV with ICU-AW is reciprocal and cannot yield clinically meaningful strategies for the prevention of ICU-AW.Prevention strategies must be based on other risk factors.Large multicentric randomized controlled trials as well as meta-analysis of such studies can be a more useful approach towards determining the influence of these risk factors on the occurrence of ICU-AW in different populations.

关 键 词：Critical illness Meta-analysis MORBIDITY MYOPATHY POLYNEUROPATHY Risk factors 

分 类 号：R459.7[医药卫生—急诊医学]