Pathological mechanism of immune disorders in diabetic kidney disease and intervention strategies  

作　　者：Tong Zhou Yi-Lin Fang Tian-Tian Tian Gui-Xia Wang 

机构地区：[1]Department of Endocrinology and Metabolism,The First Hospital of Jilin University,Changchun 130021,Jilin Province,China [2]Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education,The First Hospital of Jilin University,Changchun 130021,Jilin Province,China [3]National-Local Joint Engineering Laboratory of Animal Models for Human Diseases,Jilin University,Changchun 130021,Jilin Province,China [4]School of Public Health,Jilin University,Changchun 130021,Jilin Province,China

出　　处：《World Journal of Diabetes》2024年第6期1111-1121,共11页世界糖尿病杂志（英文版）（电子版）

基　　金：Supported by the National Natural Science Foundation of China,No.82100883;the Research Project of Educational Commission of Jilin Province of China,No.JJKH20231214KJ.

摘　　要：Diabetic kidney disease is one of the most severe chronic microvascular complications of diabetes and a primary cause of end-stage renal disease.Clinical studies have shown that renal inflammation is a key factor determining kidney damage during diabetes.With the development of immunological technology,many studies have shown that diabetic nephropathy is an immune complex disease,and that most patients have immune dysfunction.However,the immune response associated with diabetic nephropathy and autoimmune kidney disease,or caused by ischemia or infection with acute renal injury,is different,and has a complicated pathological mechanism.In this review,we discuss the pathogenesis of diabetic nephropathy in immune disorders and the intervention mechanism,to provide guidance and advice for early intervention and treatment of diabetic nephropathy.

关 键 词：Diabetic kidney disease Immune disorders Pathological mechanism Intervention strategy Kidney damage Diabetic nephropathy INFLAMMASOME IMMUNOGLOBULIN 

分 类 号：R725.8[医药卫生—儿科] R726.9[医药卫生—临床医学]