Evaluating new biomarkers for diabetic nephropathy:Role ofα2-macroglobulin,podocalyxin,α-L-fucosidase,retinol-binding protein-4,and cystatin C  

作　　者：Jing-Jing Li Ru-La Sa Yu Zhang Zhao-Li Yan 

机构地区：[1]Department of Infectious Diseases,Inner Mongolia Medical University,Hohhot First Hospital,Hohhot 010000,Inner Mongolia Autonomous Region,China [2]Department of Endocrinology,The Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010000,Inner Mongolia Autonomous Region,China [3]Department of Dermatology,Inner Mongolia Autonomous Region People’s Hospital,Hohhot 010000,Inner Mongolia Autonomous Region,China

出　　处：《World Journal of Diabetes》2024年第6期1212-1225,共14页世界糖尿病杂志（英文版）（电子版）

基　　金：pported by the Natural Science Foundation of Inner Mongolia Autonomous Region,No.2022MS08057.

摘　　要：BACKGROUND The intricate relationship between type 2 diabetes mellitus(T2DM)and diabetic nephropathy(DN)presents a challenge in understanding the significance of various biomarkers in diagnosis.AIM To elucidate the roles and diagnostic values ofα2-macroglobulin(α2-MG),podocalyxin(PCX),α-L-fucosidase(AFU),retinol-binding protein-4(RBP-4),and cystatin C(CysC)in DN.METHODS From December 2018 to December 2020,203 T2DM patients were enrolled in the study.Of these,115 were diagnosed with DN(115 patients),while the remaining 88 patients were classified as non-DN.The urinary levels ofα2-MG,PCX,and AFU and the serum concentrations RBP-4 and CysC were measured in conjunction with other relevant clinical indicators to evaluate their potential correlations and diagnostic utility.RESULTS After adjustments for age and gender,significant positive correlations were observed between the biomarkers CysC,RBP-4,α2-MG/urinary creatinine(UCr),PCX/UCr,and AFU/UCr,and clinical indicators such as urinary albumin-to-creatinine ratio(UACR),serum creatinine,urea,24-h total urine protein,and neutrophil-to-lymphocyte ratio(NLR).Conversely,these biomarkers exhibited negative correlations with the estimated glomerular filtration rate(P<0.05).Receiver operating characteristic(ROC)curve analysis further demonstrated the diagnostic performance of these biomarkers,with UACR showcasing the highest area under the ROC curve(AUC^(ROC))at 0.97.CONCLUSION This study underscores the diagnostic significance ofα2-MG,PCX,and AFU in the development of DN.The biomarkers RBP-4,CysC,PCX,AFU,andα2-MG provide promising diagnostic insights,while UACR is the most potent diagnostic biomarker in assessing DN.

关 键 词：Α2-MACROGLOBULIN Podocalysin Α-L-FUCOSIDASE Retinol binding protein-4 Cystatin C Diabetic nephropathy 

分 类 号：R587.2[医药卫生—内分泌] R542.2[医药卫生—内科学]