Effects of oral probiotics on inflammation and intestinal function in adult patients after appendectomy:Randomized controlled trial  

作　　者：Ke Lan Ke-Rui Zeng Fu-Rui Zhong Sheng-Jin Tu Jin-Long Luo Shi-Long Shu Xue-Feng Peng Hua Yang Kai Lu 

机构地区：[1]Department of General Surgery,Zigong Fourth People's Hospital,Zigong 643000,Sichuan Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2024年第5期1371-1376,共6页世界胃肠外科杂志（英文版）（电子版）

摘　　要：BACKGROUND Appendectomy is an acute abdominal surgery that is often accompanied by severe abdominal inflammation.Oral probiotics are one of the postoperative treatments for rapid rehabilitation.However,there is a lack of prospective studies on this topic after appendectomy.AIM To investigate whether the postoperative probiotics can modulate the inflammatory response and restore intestinal function in patients following appendectomy.METHODS This was a prospective,randomized trial.A total of 60 emergency patients were randomly divided into a control group(n=30)and a probiotic group(n=30).Patients in the control group started to drink some water the first day after surgery,and those in the probiotic group were given water supplemented with Bacillus licheniformis capsules for 5 consecutive days postsurgery.The indices of inflammation and postoperative conditions were recorded,and the data were analyzed with RStudio 4.3.2 software.RESULTS A total of 60 participants were included.Compared with those in the control group,the C-reactive protein(CRP),interleukin 6 and procalcitonin(PCT)levels were significantly lower in the probiotic group at 2 d after surgery(P=2.224e-05,P=0.037,and P=0.002,respectively,all P<0.05).This trend persisted at day 5 post-surgery,with CRP and PCT levels remaining significantly lower in the probiotic group(P=0.001 and P=0.043,both P<0.05).Furthermore,probiotics0.028,both P<0.05).CONCLUSION Postoperative oral administration of probiotics may modulate the gut microbiota,benefit the recovery of the early inflammatory response,and subsequently enhance recovery after appendectomy.

关 键 词：PROBIOTICS Gut microbiota APPENDECTOMY Inflammatory markers Intestinal function Enhanced recovery after surgery Postsurgical infections 

分 类 号：R574.62[医药卫生—消化系统]