New perspectives in prognostication of hepatocellular carcinoma:The role and clinical implications of transient receptor potential family genes  

作　　者：Shi-Hao Guan Wen-Jing Hu Xin-Yu Wang Yue-Xia Gu De-Hua Zhou 

机构地区：[1]Department of Plastic Surgery,Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University,Shanghai 201700,China [2]Department of Nursing,Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine,Shanghai 200434,China [3]Department of Thyroid,Breast and Vascular Surgery,Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine,Shanghai 200434,China [4]Department of Gastrointestinal Surgery,Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine,Shanghai 200434,China

出　　处：《World Journal of Gastrointestinal Oncology》2024年第6期2862-2864,共3页世界胃肠肿瘤学杂志（英文版）（电子版）

摘　　要：The study titled“Transient receptor potential-related risk model predicts prognosis of hepatocellular carcinoma patients”is a significant contribution to hepatocellular carcinoma(HCC)research,highlighting the role of transient receptor potential(TRP)family genes in the disease’s progression and prognosis.Utilizing data from The Cancer Genome Atlas database,it establishes a new risk assessment model,emphasizing the interaction of TRP genes with tumor proliferation pathways,key metabolic reactions like retinol metabolism,and the tumor immune microenvironment.Notably,the overexpression of the TRPC1 gene in HCC correlates with poorer patient survival outcomes,suggesting its potential as a prognostic biomarker and a target for personalized therapy,particularly in strategies combining immunotherapy and anti-TRP agents.

关 键 词：Hepatocellular carcinoma Transient receptor potential channels TRPC1 gene Tumor immune microenvironment Cancer prognosis Bioinformatics in cancer research 

分 类 号：R735.7[医药卫生—肿瘤]