From non-alcoholic fatty liver disease to metabolic-associated steatotic liver disease:Rationale and implications for the new terminology  

作　　者：Stephen David Howard Malnick Doron Zamir 

机构地区：[1]Department of Internal Medicine C,Kaplan Medical Center,Rehovot 76100,Israel [2]Department of Internal Medicine D,Barzilai Medical Center,Ashkelon 7830604,Israel

出　　处：《World Journal of Hepatology》2024年第6期863-866,共4页世界肝病学杂志（英文版）（电子版）

摘　　要：Non-alcoholic fatty liver disease(NAFLD)was the term first used to describe hepatic steatosis in patients with the metabolic syndrome who did not consume excess amounts of alcohol.Alcoholic liver disease(ALD)has many similarities to NAFLD in both pathogenesis and histology.This entity is now the most prevalent chronic liver disease worldwide as a consequence of the epidemic of obesity.Attempts to incorporate the importance of the metabolic syndrome in the development of steatosis resulted in the renaming of NAFLD as metabolic-associated fatty liver disease.This new term,however,has the disadvantage of the use of terms that may be perceived as derogatory.The terms fatty and non-alcoholic have negative connotations in many cultures.In addition,non-alcoholic is not usually a term applicable to pediatric cases of hepatic steatosis.Recently,an international collaborative effort,with participants from 56 countries,after a global consultation process,recommended to change the nomenclature to steatotic liver disease-including metabolic dysfunction-associated steatotic liver disease,metabolic-associated steatohepatitis and metabolic dysfunction-associated ALD.The new terminology is consistent with most of the previously published epidemiological studies and will have a major impact on research into diagnosis,prognosis and treatment.

关 键 词：Non-alcoholic fatty liver disease Steatosis metabolic-associated steatotic liver disease NOMENCLATURE 

分 类 号：R575.5[医药卫生—消化系统]