Immunological crossroads:The intriguing dance between hepatitis C and autoimmune hepatitis  

作　　者：Jonathan Soldera 

机构地区：[1]Department of Acute Medicine and Gastroenterology,University of South Wales,Cardiff CF371DL,United Kingdom

出　　处：《World Journal of Hepatology》2024年第6期867-870,共4页世界肝病学杂志（英文版）（电子版）

摘　　要：Delving into the immunological crossroads of liver diseases,this editorial explores the dynamic interplay between hepatitis C virus(HCV)and autoimmune hepatitis(AIH).While HCV primarily manifests as a viral infection impacting the liver,previous studies unveil a captivating connection between HCV and the emergence of AIH.The dance of the immune system in response to HCV appears to set the stage for an intriguing phenomenon-an aberrant autoimmune response leading to the onset of AIH.Evidence suggests a heightened presence of autoimmune markers in individuals with chronic HCV infection,hinting at a potential overlap between viral and autoimmune liver diseases.Navigating the intricate terrain of viral replication,immune response dynamics,and genetic predisposition,this editorial adds a layer of complexity to our understanding of the relationship between HCV and AIH.In this immunological crossroads,we aim to unearth insights into the complex interplay,using a compelling case where AIH and primary sclerosing cholangitis overlapped following HCV treatment with direct-acting antivirals as background.

关 键 词：Liver diseases Hepatitis C virus Autoimmune hepatitis Primary sclerosing cholangitis Inflammatory bowel disease 

分 类 号：R575.1[医药卫生—消化系统]