Clinical effect of acupuncture at ghost points combined with fluoxetine hydrochloride on mild-to-moderate depression  

作　　者：Yi Wang Qun Lu Ittipalanukul Penpat Juan Wu Dilinuer Abulikemu Fei-Cui Zeng Jia-Ying Huang Zhi-Hai Hu 

机构地区：[1]Department of Acupuncture and Moxibustion,Shanghai Hospital of Integrated Traditional Chinese and Western Medicine,The Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200082,China [2]Department of Laboratory Medicine,Shanghai Hospital of Integrated Traditional Chinese and Western Medicine,The Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200082,China [3]Department of Postgraduate Student,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China [4]Department of Radiology,Shanghai Hospital of Integrated Traditional Chinese and Western Medicine,The Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200082,China [5]Department of General Practice,Shanghai University of Traditional Chinese Medicine Affiliated Shuguang Hospital,Shanghai 200120,China [6]General Practice of Traditional Chinese Medicine,North Bund Street Community Health Service Center,Shanghai 200080,China [7]General Practice of Traditional Chinese Medicine,Shanghai Hongkou District Jiaxing Road Community Health Service Center,Shanghai 200082,China

出　　处：《World Journal of Psychiatry》2024年第6期848-856,共9页世界精神病学杂志

基　　金：Supported by the General Program of Shanghai Science and Technology Commission on Medical Innovation Research,No.21Y11923500;the Second Round of the“National Medical Strong and Excellent”Three-Year Action Plan(2022-2024)of the Hongkou District of Shanghai Traditional Chinese Medicine Schools and Characteristic Technology Inheritance Support Construction Project,No.HKGYQYXM-2022-17;the Shanghai Culture and Tourism Bureau.

摘　　要：BACKGROUND Depression is a common,chronic,and recurrent mood disorder that has become a worldwide health hazard.Fluoxetine hydrochloride,a common treatment method,can inhibit 5-hydroxytryptamine(5-HT)recycling in the presynaptic membrane;however,the efficacy of a single drug is inadequate.At present,mildto-moderate depression can be treated with acupuncture of ghost caves,but the clinical curative effect of combined therapy with fluoxetine hydrochloride has not been sufficiently reported.AIM To evaluate the clinical effect of acupuncture at ghost points combined with fluoxetine hydrochloride in the treatment of mild-to-moderate depression.METHODS This retrospective study included 160 patients with mild-to-moderate depression who were admitted to Shanghai Hospital of Integrated Traditional Chinese and Western Medicine,Affiliated to Shanghai University of Traditional Chinese Medicine,between January 2022 and June 2023.Patients were separated into a single-agent group(fluoxetine hydrochloride treatment,n=80)and a coalition group(fluoxetine hydrochloride treatment combined with acupuncture at ghost points,n=80).Pre-treatment symptoms were recorded,and the clinical curative effect and adverse reactions[Asberg Antidepressant Side Effects Scale(SERS)]were assessed.Depression before and after treatment[Hamilton Depression Scale(HAMD)-24],neurotransmitter levels[5-HT,norepinephrine(NE),dopamine(DA)],oxidative stress indicators[superoxide dismutase(SOD),malondialdehyde(MDA)],and sleep quality[Pittsburgh Sleep Quality Index(PSQI)]were compared.RESULTS The total efficacy rate was 97.50%in the coalition group and 86.25%in the single-agent group(P<0.05).After 2,4,6,and 8 wk of treatment,the HAMD,self-rating depression scale,and SERS scores of the coalition and single-agent groups decreased compared with pre-treatment,and the decrease was more significant in the coalition group(P<0.05).After 8 wk of treatment,the levels of NE,DA,5-HT,and SOD in the coalition and single-agent groups increased,while the levels of MDA decreased;th

关 键 词：DEPRESSION PRICK Fluoxetine hydrochloride Curative effect Depressive symptoms Oxidative stress index 

分 类 号：R749.4[医药卫生—神经病学与精神病学]