Risk factors and outcomes of peptic ulcer bleed in a Pakistani population:A single-center observational study  

作　　者：Nazish Butt Muhammad Tayyab Usmani Nimrah Mehak Saba Mughal Fakhar Ali Qazi-Arisar Ghulam Mohiuddin Gulzar Khan 

机构地区：[1]Department of Gastroenterology,Jinnah Postgraduate Medical Centre,Karachi 75505,Sindh,Pakistan [2]National Institute of Liver&GI Diseases,Dow University of Health Sciences,Karachi 75330,Sindh,Pakistan [3]School of Public Health,Dow University of Health Sciences,Karachi 75330,Sindh,Pakistan

出　　处：《World Journal of Gastrointestinal Pharmacology and Therapeutics》2024年第3期1-9,共9页世界胃肠药理与治疗学杂志（英文版）（电子版）

摘　　要：BACKGROUND Peptic ulcer disease(PUD)remains a significant healthcare burden,contributing to morbidity and mortality worldwide.Despite advancements in therapies,its prevalence persists,particularly in regions with widespread nonsteroidal antiinflammatory drugs(NSAIDs)use and Helicobacter pylori infection.AIM To comprehensively analyse the risk factors and outcomes of PUD-related upper gastrointestinal(GI)bleeding in Pakistani population.METHODS This retrospective cohort study included 142 patients with peptic ulcer bleeding who underwent upper GI endoscopy from January to December 2022.Data on demographics,symptoms,length of stay,mortality,re-bleed,and Forrest classification was collected.RESULTS The mean age of patients was 53 years,and the majority was men(68.3%).Hematemesis(82.4%)and epigastric pain(75.4%)were the most common presenting symptoms.Most patients(73.2%)were discharged within five days.The mortality rates at one week and one month were 10.6%and 14.8%,respectively.Re-bleed within 24 h and seven days occurred in 14.1%and 18.3%of patients,respectively.Most ulcers were Forrest class(FC)Ⅲ(72.5%).Antiplatelet use was associated with higher mortality at 7 and 30 d,while alternative medications were linked to higher 24-hour re-bleed rates.NSAID use was associated with more FCⅢulcers.Re-bleed at 24 h and 7 d was strongly associated with one-week or one-month mortality.CONCLUSION Antiplatelet use and rebleeding increase the risk of early mortality in PUD-related upper GI bleeding,while alternative medicines are associated with early rebleeding.

关 键 词：Non variceal bleed MORTALITY Re-bleed Forrest classification ANTIPLATELETS Alternative medicines 

分 类 号：R573.1[医药卫生—消化系统]