Hepatocellular carcinoma-the role of the underlying liver disease in clinical practice  

作　　者：Angelo Zambam de Mattos Isadora Zanotelli Bombassaro Arndt Vogel Jose D Debes 

机构地区：[1]Department of Internal Medicine,Universidade Federal de Ciências da Saúde de Porto Alegre,RS,Porto Alegre 90020090,Brazil [2]Graduate Program in Medicine:Hepatology,Federal University of Health Sciences of Porto Alegre,RS,Porto Alegre 90050-170,Brazil [3]Division of Gastroenterology Hepatology,University of Toronto,Hannover M5R 0A3,Canada [4]Department of Medicine,University of Minnesota,Minneapolis,MN 55455,United States

出　　处：《World Journal of Gastroenterology》2024年第19期2488-2495,共8页世界胃肠病学杂志（英文版）

基　　金：Supported by European-Latin American ESCALON Consortium,EU Horizon 2020 Program,No.825510;National Institutes of Health,No.NIH R21 TW012390-01A1.

摘　　要：Hepatocellular carcinoma(HCC)is one of the most common causes of cancerrelated mortality.This particular type of cancer has the distinctive characteristic of mostly happening in individuals with an underlying liver disease.This makes the management of patients more challenging,since physicians must take into consideration two different conditions,the chronic liver disease and the tumor.The underlying liver disease has several implications in clinical practice,because different kinds of chronic liver disease can lead to varying degrees of risk of developing HCC,obstacles in surveillance,and differences in the efficacy of the treatment against HCC.A shift in the prevalence of liver diseases has been evident over the last few years,with viral hepatitis gradually losing the leading position as cause of HCC and metabolic dysfunction-associated steatotic liver disease gaining importance.Therefore,in an era of personalized medicine,it is imperative that physicians are aware of the underlying liver disease of individuals with HCC and its impact in the management of their tumors.

关 键 词：Hepatocellular carcinoma ETIOLOGY EPIDEMIOLOGY SURVEILLANCE THERAPY 

分 类 号：R575.5[医药卫生—消化系统] R735.7[医药卫生—内科学]