Future of neurocritical care:Integrating neurophysics,multimodal monitoring,and machine learning  

作　　者：Bahadar S Srichawla 

机构地区：[1]Department of Neurology,University of Massachusetts Chan Medical School,Worcester,MA 01655,United States

出　　处：《World Journal of Critical Care Medicine》2024年第2期29-48,共20页世界重症医学杂志

摘　　要：Multimodal monitoring(MMM)in the intensive care unit(ICU)has become increasingly sophisticated with the integration of neurophysical principles.However,the challenge remains to select and interpret the most appropriate combination of neuromonitoring modalities to optimize patient outcomes.This manuscript reviewed current neuromonitoring tools,focusing on intracranial pressure,cerebral electrical activity,metabolism,and invasive and noninvasive autoregulation moni-toring.In addition,the integration of advanced machine learning and data science tools within the ICU were discussed.Invasive monitoring includes analysis of intracranial pressure waveforms,jugular venous oximetry,monitoring of brain tissue oxygenation,thermal diffusion flowmetry,electrocorticography,depth electroencephalography,and cerebral microdialysis.Noninvasive measures include transcranial Doppler,tympanic membrane displacement,near-infrared spectroscopy,optic nerve sheath diameter,positron emission tomography,and systemic hemodynamic monitoring including heart rate variability analysis.The neurophysical basis and clinical relevance of each method within the ICU setting were examined.Machine learning algorithms have shown promise by helping to analyze and interpret data in real time from continuous MMM tools,helping clinicians make more accurate and timely decisions.These algorithms can integrate diverse data streams to generate predictive models for patient outcomes and optimize treatment strategies.MMM,grounded in neurophysics,offers a more nuanced understanding of cerebral physiology and disease in the ICU.Although each modality has its strengths and limitations,its integrated use,especially in combination with machine learning algorithms,can offer invaluable information for individualized patient care.

关 键 词：Neurocritical care Critical care Multimodal monitoring Machine learning Neurophysics Cerebral hemodynamics Cerebral energetics Transcranial Doppler Cerebral microdialysis Near-infrared spectroscopy 

分 类 号：R741[医药卫生—神经病学与精神病学] TP18[医药卫生—临床医学]