Endoscopic full-thickness plication along with argon plasma coagulation for treatment of proton pump inhibitor dependent gastroesophageal reflux disease  

作　　者：Yogesh Harwani Shreya Butala Balaji More Varun Shukla Anand Patel 

机构地区：[1]Department of Gastroenterology,Nobel Gastro Hospital,Ahmedabad 408409,Gujarat,India [2]Department of Gastroenterology,Sanjay Gandhi Post Graduate Institute of Medical Sciences,Lucknow 226014,Uttar Pradesh,India [3]Department of Pharmacology,Mahatma Gandhi Medical College and Research Institute,Puducherry 607402,Puducherry,India [4]Department of Gastroenterology,Noble Institute of Gastroenterology,Ahmedabad 380009,Gujrat,India

出　　处：《World Journal of Gastrointestinal Endoscopy》2024年第5期250-258,共9页世界胃肠内镜杂志（英文版）（电子版）

摘　　要：BACKGROUND Most endoscopic anti-reflux interventions for gastroesophageal reflux disease(GERD)management are technically challenging to practice with inadequate data to support it utility.Therefore,this study was carried to evaluate the effectiveness and safety newer endoscopic full-thickness fundoplication(EFTP)device along with Argon Plasma Coagulation to treat individuals with GERD.AIM To evaluate the effectiveness and safety newer EFTP device along with Argon Plasma Coagulation to treat individuals with GERD.METHODS This study was a single-center comparative analysis conducted on patients treated at a Noble Institute of Gastroenterology,Ahmedabad,hospital between 2020 and 2022.The research aimed to retrospectively analyze patient data on GERD symptoms and proton pump inhibitor(PPI)dependence who underwent EFTP using the GERD-X system along with argon plasma coagulation(APC).The primary endpoint was the mean change in the total gastroesophageal reflux disease health-related quality of life(GERD-HRQL)score compared to the baseline measurement at the 3-month follow-up.Secondary endpoints encompassed enhancements in the overall GERD-HRQL score,improvements in GERD symptom scores at the 3 and changes in PPI usage at the 3 and 12-month time points.RESULTS In this study,patients most were in Hill Class II,and over half had ineffective esophageal motility.Following the EFTP procedure,there were significant improvements in heartburn and regurgitation scores,as well as GERDHRQL scores(P<0.001).PPI use significantly decreased,with 82.6%not needing PPIs or prokinetics at end of 1 year.No significant adverse events related to the procedures were observed in either group.CONCLUSION The EFTP along with APC procedure shows promise in addressing GERD symptoms and improving patients'quality of life,particularly for suitable candidates.Moreover,the application of a lone clip with APC yielded superior outcomes and exhibited greater cost-effectiveness.

关 键 词：Gastroesophageal reflux disease ENDOSCOPY Quality of life Endoscopic antireflux interventions Retrospective data analysis Gastroesophageal reflux disease symptom scores Proton pump inhibitor 

分 类 号：R735.31[医药卫生—肿瘤]