Effect of vinegar supplementation on patients with esophageal lesions lightly stained with Lugol’s iodine solution:Prospective single-centre trial  

作　　者：Yuan Gao Lian-Song Ye Xu Li Bin Yu Ke Liao Jia Xie Jiang Du Qiong-Ying Zhang Bing Hu 

机构地区：[1]Department of Gastroenterology and Hepatology,Digestive Endoscopy Medical Engineering Research Laboratory,West China Hospital,Med-X Center for Materials,Sichuan University,Chengdu 610041,Sichuan Province,China [2]Design,Measurement and Evaluation(CBDME),Department of Clinical Research Management,West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China [3]Institute for Disaster Management and Reconstruction,Sichuan University-The Hong Kong Polytechnic University,Chengdu 610065,Sichuan Province,China [4]West China School of Public Health and West China Fourth Hospital,Sichuan University,Chengdu 610044,Sichuan Province,China [5]Precision Medicine Research Center,West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China

出　　处：《World Journal of Gastrointestinal Endoscopy》2024年第5期259-272,共14页世界胃肠内镜杂志（英文版）（电子版）

基　　金：Supported by the 1-3-5 Project for Disciplines of Excellence-Clinical Research Incubation Project,West China Hospital,Sichuan University,No.2020HXFH016;the Med-X Innovation Programme of Med-X Center for Materials,Sichuan University,No.MCM202302;The study protocol was approved by the Biomedical Research Ethics Committee,West China Hospital of Sichuan University(No.HX-IRB-AF-03-V3.0).

摘　　要：BACKGROUND Esophageal chromoendoscopy with iodine solution is important for detecting early esophageal cancer.The effect of routine treatment for lesions lightly stained with Lugol’s iodine solution is limited,and the addition of natural substances to a regular diet is becoming increasingly common.Vinegar has antitumor effects as reported in previous studies.AIM To evaluate whether vinegar supplementation could improve the prognosis of patients with lightly stained esophageal lesions.METHODSThis prospective single-centre trial included consecutive patients with lightly stained lesions between June 2020 and April 2022.Patients in the experimental group received increased amounts of vinegar for 6 months.The primary outcome of the study was the clinical therapeutic effect.Complications related to vinegar ingestion and adverse events were also recorded in detail.RESULTS A total of 166 patients were included in the final analysis.There was no significant difference in the baseline data between the two groups.Intention-to-treat(ITT)analysis demonstrated that the rates at which endoscopic characteristics improved were 33.72%in the experimental group and 20.00%in the conventional group(P=0.007);and the rates at which biopsy pathology improved were 19.77%and 8.75%,respectively(P=0.011).Additional vinegar consumption had a statistically protective effect on the rate at which endoscopic characteristics improved[hazard ratio(HR)_(ITT)=2.183,95%CI:1.183-4.028;HR_(per-protocol(PP))=2.307,95%CI:1.202-4.426]and biopsy pathology improved(HR_(ITT)=2.931,95%CI:1.212-7.089;HR_(PP)=3.320,95%CI:1.295-8.507).No statistically significant effect of increased vinegar consumption on preventing high-grade intraepithelial neoplasia or early cancer was observed(HR_(ITT)=0.382,95%CI:0.079-1.846;HRPP=0.382,95%CI:0.079-1.846).The subgroup analyses indicated that the overall therapeutic improvement of endoscopic characteristics and biopsy pathology seemed more obvious in older(age>60)male patients with small lesions(lesion size≤0.5 cm).Three

关 键 词：CHROMOENDOSCOPY Esophageal squamous epithelium VINEGAR Atypical hyperplasia Prognosis 

分 类 号：R574.62[医药卫生—消化系统]