氯胺酮抗抑郁药物动力学及临床不良反应研究进展  

Research progress of antidepressant pharmacokinetics and clinical adverse effects of ketamine

作　　者：夏蕴轩 魏萌(综述) 刘燕(审校) XIA Yunxuan;WEI Meng;LIU Yan(School of Mental Health,Jining Medical University,Jining 272013,China;School of Psychology,Shandong Normal University,Jinan 250358,China;School of Public Health,Jining Medical University,Jining 272013,China;Center of Evidence-Based Medicine,Jining Medical University,Jining 272013,China)

机构地区：[1]济宁医学院精神卫生学院,济宁272013 [2]山东师范大学心理学院,济南250358 [3]济宁医学院公共卫生学院,济宁272013 [4]济宁医学院循证医学中心,济宁272013

出　　处：《济宁医学院学报》2024年第3期253-256,共4页Journal of Jining Medical University

基　　金：济宁医学院大学生创新创业计划项目(cx2020009);泰山学者青年专家人才项目(tsqn201909145)。

摘　　要：当前临床应用的抗抑郁药物存在起效慢、缓解率低等不足。氯胺酮通过多重互补的抗抑郁机制和独特的药代动力学特点表现出了优异的快速抗抑郁作用,且患者耐受性较好。本文对氯胺酮的抗抑郁作用药物动力学及临床不良反应进行综述。The current clinical antidepressants have the disadvantages of slow onset and low remission rate.Ketamine had showed excellent rapid antidepressant effect through multiple complementary antidepressant mechanisms and unique pharmacokinetic characteristics,and was well tolerated by patients.This paper reviews the pharmacokinetics and side effects of ketamine antidepressant effect.

关 键 词：氯胺酮 药代动力学 不良反应 

分 类 号：R749.4[医药卫生—神经病学与精神病学]