雄激素受体在肿瘤中的作用及机制研究进展  

Research progress on the role and mechanism of androgen receptors in tumors

作　　者：游志喜 李媛媛[1,2] 雷烨 YOU Zhixi;LI Yuanyuan;LEI Ye(Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712046,China;Scientific Research Department,the Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712046,China;Department of Endocrinology and Metabolism,the Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712046,China)

机构地区：[1]陕西中医药大学,陕西咸阳712046 [2]陕西中医药大学第二附属医院科研科,陕西咸阳712046 [3]陕西中医药大学第二附属医院内分泌代谢科,陕西咸阳712046

出　　处：《现代肿瘤医学》2024年第12期2287-2291,共5页Journal of Modern Oncology

基　　金：国家自然科学基金项目青年科学基金项目(编号:82104464);第二批省级中医药优秀中青年科技骨干人才专项科研项目(编号:2023-ZQNY-013);陕西省咸阳市科技局重点研发计划项目(编号:L2022ZDYFSF014);陕西中医药大学研究生质量提升工程专项项目-研究生创新实践能力提升项目(编号:CXSJ202315)。

摘　　要：雄激素受体(androgen receptor, AR)是类固醇核受体超家族的成员之一。AR在正常生理和代谢过程以及在肿瘤等多种疾病的发生与发展中起着重要作用。AR在不同肿瘤中作用不同,如在前列腺癌、黑色素瘤及胃癌等肿瘤中发挥促进作用,而在雌激素受体阳性乳腺癌中发挥肿瘤抑制作用。AR通过调节免疫(抑制肿瘤浸润性CD8^(+)T细胞的活性和干性)间接发挥促进肿瘤发生发展。该文回顾并总结AR在肿瘤中的主要作用、分子机制与最新研究进展,阐明AR的研究前景,为AR的进一步研究提供思路。Androgen receptor(AR)is a member of the steroid nuclear receptor superfamily.AR plays an important role in normal physiological and metabolic processes as well as in the onset and progression of a variety of diseases,including tumors.AR plays different roles in different tumors.For example,it acts as a promoter in prostate cancer,melanoma,and gastric cancer,and as a tumor suppressor in estrogen receptor-positive breast cancer.AR plays an indirect role in promoting tumorigenesis and progression by modulating immunity(suppressing the activity and stemness of tumor-infiltrating CD8^(+)T cells).This paper reviews and summarizes the main role,molecular mechanism and recent research progress of AR in tumors,elucidates the research prospect of AR,and provides ideas for further research on AR.

关 键 词：雄激素受体 肿瘤 促肿瘤因子 肿瘤抑制因子 靶向治疗 

分 类 号：R73[医药卫生—肿瘤]