利用两样本孟德尔随机化方法探究复方口服避孕药与乳腺癌发病风险的关系  

Two sample Mendelian randomization method was used to investigate the relationship between combined oral contraceptives and the risk of breast cancer

作　　者：邓佳琳 江涛 石玉琳 邱锡鹏[2] 许家佗[1] DENG Jialin;JIANG Tao;SHI Yulin;QIU Xipeng;XU Jiatuo(College of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;School of Computer Science,Fudan University,Shanghai 200433,China)

机构地区：[1]上海中医药大学中医学院,上海201203 [2]复旦大学计算机学院,上海200433

出　　处：《现代肿瘤医学》2024年第11期2020-2024,共5页Journal of Modern Oncology

基　　金：国家自然科学基金青年科学基金项目(编号:82305090,82104738);科技部“十三五”国家重点研发计划中医药现代化研究重点专项项目(编号:2017YFC1703301)。

摘　　要：目的:利用两样本孟德尔随机化方法探究评估抗复方口服避孕药(combined oral contraceptive,COC)对乳腺癌风险的影响。方法:对基于与COC高度相关的单核苷酸多态性的全基因组关联研究的合并数据进行二次数据分析,并选择雌激素和孕激素水平作为工具变量,分别采用逆方差加权、MR-Egger回归和加权中位数方法进行两样本孟德尔随机化分析,以评估COC、雌激素及孕激素与乳腺癌和ER^(+)/ER^(-)乳腺癌之间的关联。我们分别采用逆方差加权、MR-Egger回归和加权中位数方法进行两样本孟德尔随机化分析。最后进行敏感性分析来评估结果的稳定性和可靠性。结果:逆方差加权、MR-Egger回归和加权中位数方法三种方法均显示COC的使用与乳腺癌(包括ER^(+)/ER^(-)乳腺癌)的发生无显著风险关联(P均>0.05)。结论:孟德尔随机化结果显示COC的使用与乳腺癌发病风险之间无关。Objective:To evaluate the effect of combined oral contraceptive COC on breast cancer risk using a two-sample Mendelian randomisation(MR)method.Methods:A secondary data analysis was conducted on the combined data of genome-wide association studies based on single nucleotide polymorphisms highly correlated with COC,and estrogen and progesterone levels were selected as instrumental variables.The two-sample Mendelian randomization analysis was conducted by inverse variance weighting,MR-Egger regression and weighted median,respectively,to evaluate the association of COC,estrogen,and progesterone with breast cancer and ER^(+)/ER^(-) breast cancer.We used inverse variance weighting,MR-Egger regression and weighted median respectively to carry out two-sample Mendelian randomization analysis.Finally,sensitivity analysis was performed to evaluate the stability and reliability of the results.Results:Three methods(inverse variance weighting,MR-Egger regression and weighted median method),all showed that COC use was not significantly associated with the risk of breast cancer(including ER^(+)/ER^(-)breast cancer)(P>0.05).Conclusion:Mendelian randomization showed no correlation between COC use and breast cancer risk.

关 键 词：复方口服避孕药 雌激素 乳腺癌 孟德尔随机化 

分 类 号：R737.9[医药卫生—肿瘤]