小泛素样修饰(SUMO)与肿瘤发生发展的机制研究进展  

SUMO modification and its research progress in tumors

作　　者：王微[1] 孙峥嵘[1] WANG Wei;SUN Zhengrong(Shengjing Hospital of China Medical University,Liaoning Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院,辽宁沈阳110004

出　　处：《现代肿瘤医学》2024年第11期2084-2088,共5页Journal of Modern Oncology

基　　金：辽宁省应用基础研究计划(编号:2022JH2/101500045)。

摘　　要：泛素样小分子修饰物(SUMO)是一种可逆的翻译后修饰。作为一种重要的分子调控机制,它在DNA损伤修复、机体免疫应答、癌变、调控细胞周期和细胞凋亡过程中发挥着关键作用。SUMO广泛参与肿瘤发生、癌细胞增殖和转移,但其导致恶性肿瘤发生的分子调控机制尚未完全明确。深入探究SUMO修饰在各类癌症发生中的分子机制,将为恶性肿瘤的诊断、治疗及预防提供新的分子靶点。该文对SUMO的修饰过程进行了简要概括,并对SUMO蛋白在多种癌症中的作用进行了综述。Small ubiquitin-like modifier(SUMO),a reversible post-translational modification,has emerged as an important molecular regulatory mechanism that plays a key role in the regulation of DNA damage repair,immune response,canceration,cell cycle progression,and apoptosis.SUMO modification is widely involved in tumorigenesis,proliferation and metastasis of cancer cells.However,the molecular mechanism of SUMO modification leading to the occurrence and development of malignant tumors have not been fully clarified.An in-depth study of the role of sumoization in the progression of various cancers will provide a new method for the diagnosis,treatment and prevention of malignant tumors.In this paper,we reviewed the process of SUMO modification,and the roles of SUMO proteins in a variety of cancers.

关 键 词：泛素样小分子修饰物 翻译后修饰 肿瘤 分子机制 

分 类 号：R730[医药卫生—肿瘤]