盆腔肿瘤放化疗诱导急性血液学毒性机制及预测工具研究进展  

esearch progress on the mechanisms and predictive tools for acute hematological toxicity induced by pelvic tumor chemoradiotherapy

作　　者：郝洋 秦思源 郎宁[2] HAO Yang;QIN Siyuan;LANG Ning(Peking University Health Science Center,Beijing 100191,China;Peking University Third Hospital,Beijing 100191,China)

机构地区：[1]北京大学医学部,北京100191 [2]北京大学第三医院,北京100191

出　　处：《现代肿瘤医学》2024年第11期2099-2104,共6页Journal of Modern Oncology

基　　金：国家自然科学基金资助项目(编号:82371921)。

摘　　要：放化疗(chemoradiotherapy,CRT)是盆腔肿瘤治疗的重要方式,主要适用于宫颈癌和直肠癌等疾病。然而,尽管CRT在产生治疗效果的同时也可能对盆腔骨髓造成损伤,导致急性血液学毒性(hematological toxicity,HT)的发生。准确识别CRT诱发HT高风险人群对于优化治疗方案和改善预后非常重要。该文总结了急性HT的发生机制,并且从临床危险因素、放化疗相关因素、影像学预测手段以及人工智能等几个方面对急性HT的预测工具进行了综述。Chemoradiotherapy(CRT)is an important therapeutic approach for pelvic tumors,particularly in the treatment of cervical cancer and rectal cancer.However,despite its therapeutic benefits,CRT may also cause damage to the pelvic bone marrow,leading to the occurrence of hematological toxicity(HT).Accurate identification of high-risk individuals susceptible to CRT-induced HT is crucial for optimizing treatment strategies and improving prognosis.This article provides a comprehensive review of the mechanisms underlying acute HT and discusses predictive tools for acute HT from various perspectives,including clinical risk factors,CRT-related factors,imaging-based prediction methods,and artificial intelligence.

关 键 词：放化疗 盆腔肿瘤 血液学毒性 发病机制 预测工具 

分 类 号：R739.9[医药卫生—肿瘤]