眼眶淋巴瘤的鉴别诊断和治疗进展  

Advances in differential diagnosis and treatment of orbital lymphoma

作　　者：陈虹霖 张积[1] CHEN Honglin;ZHANG Ji(The Second Affiliated Hospital of Soochow University,Jiangsu Suzhou 215000,China)

机构地区：[1]苏州大学附属第二医院,江苏苏州215000

出　　处：《现代肿瘤医学》2024年第11期2109-2114,共6页Journal of Modern Oncology

基　　金：江苏省苏州市医学重点扶持学科(编号:SZFCXK202118);2023年度江苏省科技计划专项资金面上项目(编号:BK20231201);2023年度省部共建放射医学与防护国家重点实验室开放课题(编号:GZK1202305)。

摘　　要：淋巴瘤是成人最常见的眼眶恶性肿瘤,绝大多数起源于B细胞,其中黏膜相关性淋巴组织结外边缘区B细胞淋巴瘤(MALT)是最常见的亚型,其次是弥漫性大B细胞淋巴瘤(DLBL)、滤泡性淋巴瘤(FL)和套细胞淋巴瘤(MCL)。疾病的组织病理学亚型和临床分期是患者预后的最佳指标。眼眶淋巴瘤缺少影像学特征,需结合临床表现、组织学、分子生物学检查结果与其他眼眶病变进行鉴别。治疗方法包括手术、放射治疗、化学治疗、免疫治疗、靶向治疗等。治疗眼眶淋巴瘤时必须考虑亚型分类及TNM分期。该文对近年来眼眶淋巴瘤的诊疗进展进行总结,为临床工作提供参考。Lymphoma is one of the most common orbital malignant tumors in adults.Most orbital lymphomas originate from B cells,of which mucosa-associated lymphoid tissue extranodul marginal zone lymphoma(MALT)is the most common subtype,followed by diffuse large B-cell lymphoma(DLBL),follicular lymphoma(FL)and mantle cell lymphoma(MCL).The histopathological subtypes and clinical stages of the disease are the best indicators of prognosis.Orbital lymphoma lacks imaging features and should be differentiated from other orbital lesions according to the results of clinical manifestations,histology and molecular biology.The treatment of orbital lymphoma includes surgery,radiotherapy,chemotherapy,immunotherapy,targeted therapy and so on.Subtype classification and TMN staging must be considered in the treatment of orbital lymphoma.This article summarizes the progress in the diagnosis and treatment of orbital lymphoma in recent years,in order to provide reference for clinical work.

关 键 词：眼眶肿瘤 淋巴瘤 治疗 鉴别 早期诊断 

分 类 号：R739.72[医药卫生—肿瘤]