痛泻要方对腹泻型肠易激综合征患者炎症因子表达的影响  

Effect of Tongxie decoction on expression of inflammatory factors in patients with diarrheal irritable bowel syndrome

作　　者：史先芳 刘铁梅 何桂钧 SHI Xian-fang;LIU Tie-mei;HE Gui-jun(Department of Gastroenterology,Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University,Shanghai 201799,China;Endoscopy Center,Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University,Shanghai 201799,China)

机构地区：[1]复旦大学附属中山医院青浦分院消化科,上海201799 [2]复旦大学附属中山医院青浦分院内镜中心,上海201799

出　　处：《哈尔滨医科大学学报》2024年第1期15-19,共5页Journal of Harbin Medical University

基　　金：青浦区卫生健康委员会科研项目(W2013-07)。

摘　　要：目的探讨痛泻要方对腹泻型肠易激综合征(diarrheal irritable bowel syndrome,IBS-D)患者血清肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-1β(interleukin-1β,IL-1β)及白细胞介素-10(interleukin-10,IL-10)表达水平的影响。方法选取2020年1月~2023年1月复旦大学附属中山医院青浦分院收治的腹泻型肠易激综合征患者64例,按照随机数字表法分为两组,益生菌组32例,予口服整肠生;中药组32例,予痛泻要方治疗;对照组为32例健康体检人员。观察对照组血清炎症因子表达情况及治疗前后益生菌组、中药组主要临床症状评分、临床有效率及血清TNF-α、IL-1β及IL-10水平变化。结果中药组和益生菌组治疗后症状均明显改善,差异有统计学意义(P<0.05)。与益生菌组比较,中药组具有相对较低的临床评分,有效率高于益生菌组,差异均有统计学意义(P<0.05)。治疗前腹泻型IBS-D患者血清TNF-α、IL-1β表达水平高于对照组,IL-10表达水平低于对照组,差异具有统计学意义(P<0.05)。治疗后中药组与益生菌组比较,血清TNF-α、IL-1β及IL-10水平表达差异有统计学意义(P<0.05)。中药组和益生菌组治疗前后血清TNF-α、IL-1β及IL-10水平表达差异有统计学意义(P<0.05)。结论痛泻要方能够明显改善腹泻型肠易激综合征患者临床症状,治疗效果确切,可减轻炎症反应,其作用机制可能与血清TNF-α、IL-1β及IL-10表达水平有关。Objective To investigate the effects of Tongxie decoction on the expression levels of tumor necrosis factor⁃α(TNF⁃α),interleukin⁃1β(IL⁃1β)and interleukin⁃10(IL⁃10)in serum of patients with diarrheal irritable bowel syndrome(IBS⁃D).Methods Sixty⁃four cases of IBS⁃D of Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University from January 2020 to January 2023 were collected,they were divided into two groups according to random number table method.The probiotic group was given oral Zhengchangsheng(n=32),the Chi⁃nese medicine group was given Tongxie decoction(n=32),and the control group consisted of 32 healthy physical examination personnel.The expression of serum inflammatory factors in the control group and the changes of serum TNF⁃α,IL⁃1βand IL⁃10 before and after treatment in the probiotic group and the Chinese medicine group were observed.Results Symptoms in both the Chinese medicine group and the probiotic group were significantly improved after treatment,with statistical significance(P<0.05).The clinical symptom score in the Chinese medicine group was lower than that in the probiotic group,and the effective rate was higher than that in the probiotic group,with statistical significance(P<0.05).Before treatment,the serum ex⁃pression levels of TNF⁃αand IL⁃1βin IBS⁃D patients were higher than those in control group,and IL⁃10 was lower than those in control group,with statistical significance(P<0.05).After treatment,the levels of TNF⁃α,IL⁃1βand IL⁃10 between Chinese medicine group and probiot⁃ic group were significantly different(P<0.05).There were significant differences in the ex⁃pression levels of TNF⁃α,IL⁃1βand IL⁃10 in the Chinese medicine group and the probiotic group before and after treatment(P<0.05).Conclusion Tongxie decoction can obviously improve the clinical symptoms of patients with diarrheal irritable bowel syndrome,and has defi⁃nite therapeutic effect,and can reduce the inflammatory response,the mechanism of which may be rela

关 键 词：痛泻要方 整肠生 肠易激综合 炎症因子 

分 类 号：R574.62[医药卫生—消化系统]